Evidence map›Paper›PMID 31949886›Full record

ArticleOxidative medicine and cellular longevity2019

Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism.

Roberto Arriga, Francesca Pacifici, Barbara Capuani, Andrea Coppola, Augusto Orlandi, Maria Giovanna Scioli, Donatella Pastore, Aikaterini Andreadi, Paolo Sbraccia, Manfredi Tesauro and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
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  6. Obesity Modifies the Proteomic Profile of the Periodontal Ligament.International journal of molecular sciences · 2023
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  10. Review
  11. Article
  12. Review
  13. Redox Regulation of Lipid Mobilization in Adipose Tissues.Antioxidants (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Glutathione S-Transferases in Cancer.Antioxidants (Basel, Switzerland) · 2021
    Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Roberto ArrigaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-1407-7995
Francesca PacificiDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Barbara CapuaniDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Andrea CoppolaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Augusto OrlandiDepartment of Anatomic Physiology, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0001-7202-5854
Maria Giovanna ScioliDepartment of Anatomic Physiology, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-8458-4108
Donatella PastoreDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-2284-6256
Aikaterini AndreadiDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0003-2294-5833
Paolo SbracciaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0001-9634-1501
Manfredi TesauroDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Nicola Di DanieleDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0001-7671-0015
Giuseppe SconocchiaLaboratory of Tumor Immunology and Immunotherapy, Institute of Translational Pharmacology, Department of Biomedicine, National Research Council (CNR), Rome, Italy.ORCID https://orcid.org/0000-0003-3260-4856
Giulia DonadelDepartment of Clinical Science and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-2454-5940
Alfonso BelliaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
David Della-MorteDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-4054-5318
Davide LauroDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-8597-4415
University of Rome Tor Vergata · ITIstituto di Farmacologia Traslazionale · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin action and often glucose-stimulated insulin secretion are reduced in obesity. In addition, the excessive intake of lipids increases oxidative stress leading to overt type 2 diabetes mellitus (T2DM). Among the antioxidative defense systems, peroxiredoxin 6 (PRDX6) is able to reduce H

Indexed as

AdipogenesisLipid MetabolismAnimalsAntioxidantsBlood GlucoseDiet, High-FatFemaleInsulinInsulin ResistanceInsulin-Secreting CellsMaleMiceMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseaseObesityAntioxidantsBlood GlucoseInsulinPeroxiredoxin VIPrdx6 protein, mouse

Identifiers

PMID31949886
PMCPMC6948322
OpenAlexW2994908079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.