Evidence map›Paper›PMID 31949876›Full record

ArticleOxidative medicine and cellular longevity2019

Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice.

Yue Wu, Jinwei Pang, Jianhua Peng, Fang Cao, Zongduo Guo, Li Jiang, Zhipeng Teng, Zhijian Huang, Chongjie Cheng, Yong Jiang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 88 citations in OpenAlex.

  1. EML4-ALK fusion rewires transcriptomic, miRNA, and CAF-associated programs in non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yue WuDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jinwei PangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jianhua PengDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Fang CaoDepartment of Cerebrovascular Disease, The Affiliated Hospital of Zunyi Medical College, Zunyi, China.
Zongduo GuoDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-3415-9293
Li JiangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhipeng TengDepartment of Neurosurgery, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Zhijian HuangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chongjie ChengDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-0680-2448
Yong JiangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0002-0490-3405
Xiaochuan SunDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-6992-332X
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNAffiliated Hospital of Southwest Medical University · CNAffiliated Hospital of Zunyi Medical College · CNFirst People's Hospital of Chongqing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal injury is the primary cause of poor outcome after subarachnoid hemorrhage (SAH). The apolipoprotein E (APOE) gene has been suggested to be involved in the prognosis of SAH patients. However, the role of APOE in neuronal injury after SAH has not been well studied. In this study, SAH was induced in APOE-knockout (APOE

Indexed as

AnimalsApolipoproteins EApoptosisBrain InjuriesDisease Models, AnimalInflammationJNK Mitogen-Activated Protein KinasesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMitogen-Activated Protein Kinase 8NeuronsSignal TransductionSubarachnoid HemorrhageApolipoproteins EJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein Kinase 8

Identifiers

PMID31949876
PMCPMC6944964
OpenAlexW2997920261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.