ArticleInternational journal of clinical and experimental pathology2018
Prognostic signifcance of IL35 expression in human hepatocellular carcinoma.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Current Advancements in Serum Protein Biomarkers for Hepatitis B Virus-Associated Hepatocyte Remodeling and Hepatocellular Carcinoma.Immunity, inflammation and disease · 2025Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectThis study was performed to explain the underlying role of IL35 on the prognosis of patients with HCC.
methodsThe expression of IL35 at the protein level was detected with immunohistochemistry (IHC). Chi-square test was performed to analyze the relationship between IL35 expression and clinical parameters of HCC patients. The correlation between expression level of IL35 and the prognosis of patients with HCC was evaluated by Kaplan-Meier method and Cox regression method.
resultsThe positive rate of IL35 expression in HCC samples was about 62.7%, which was significantly higher than that in paired normal specimens (12%). The analyses suggested that there was no correlation between IL35 expression and age, gender, and tumor size (P>0.05), but a tight relationship was found between IL35 expression and metastasis, AFP, HBV infection, Child-Pugh (P<0.05). Susequent Kaplan-Meier analysis result indicated that positive expression of IL35 induced low survival rate of HCC patients, and the Cox regression analysis suggested that IL35 might be a biomarker for prognosis of patients with HCC.
conclusionGenerally, results of this study demonstrated that expression of IL35 shared a close association with the prognosis of patients with HCC. Therefore, IL35 could be considered as a novel index for prognosis of patients with HCC.
Indexed as
Identifiers
31949870PMC6962944W3001360059What OpenQuestion holds
Registered trials
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