ArticleInternational journal of clinical and experimental pathology2018
miR-196 acts as a tumor suppressor in osteosarcoma by targeting HOXA9.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Molecular features and vulnerabilities of recurrent chordomas.Journal of experimental & clinical cancer research : CR · 2021Article
- MiRNAs in Canine and Human Osteosarcoma: A Highlight Review on Comparative Biomolecular Aspects.Cells · 2021Review
- Phenytoin Inhibits Cell Proliferation through microRNA-196a-5p in Mouse Lip Mesenchymal Cells.International journal of molecular sciences · 2021Article
- miR-140 and miR-196a as Potential Biomarkers in Breast Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2020Article
Corrections and comments
- Retraction · 2021-06-15Concerns/Issues about Data · Original Data and/or Images not Provided and/or not Available · Results Not Reproducible · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal expression of microRNAs (miRNAs) has been found in most cancer types. Therefore, the discovery of miRNAs could help us to understand the mechanism of tumor initiation and development. The purpose of this study was to investigate the significance of miR-196 in osteosarcoma (OS) and to identify its target genes. We found miR-196 expression was significantly reduced in OS tissues and cell lines (Saos-2 and MG-63) as compared to normal tissues and cell line. The OS cell line proliferation and migration abilities were inhibited by miR-196 overexpression but promoted by miR-196 downregulation
Indexed as
Identifiers
31949856PMC6962975W3004559441What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.