ArticleInternational journal of clinical and experimental pathology2018
Characteristics of peripheral and intrahepatic regulatory B cells in HBV-related liver cirrhosis.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Effects of laparoscopic splenectomy and azygoportal disconnection on immune remodeling in cirrhosis patients with portal hypertension bleeding: a 1-year prospective study.Surgical endoscopy · 2026Article
- Immune Dysfunction and Infection Risk in Advanced Liver Disease.Gastroenterology · 2025Review
- Vaccine Responses in Patients with Liver Cirrhosis: From the Immune System to the Gut Microbiota.Vaccines · 2024Review
- Regulatory B Cells Dysregulated T Cell Function in an IL-35-Dependent Way in Patients With Chronic Hepatitis B.Frontiers in immunology · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory B (Breg) cells have been demonstrated to play a suppressive role in chronic hepatitis B virus infection. However, the role of Breg in HBV-related liver cirrhosis has not been determined. Patients with chronic hepatitis B virus infection and HBV-related liver cirrhosis were enrolled. Frequencies of peripheral B cell subsets were assessed by flow cytometry. Intrahepatic B cells, IL-10 positive cells and Breg cells were determined by immunohistochemistry. We found that frequency of peripheral Breg cells was significantly higher in cirrhotic patients compared with that in healthy volunteers. Further, the amount of intrahepatic Breg cells was elevated in patients with HBV-related liver cirrhosis. We identified a positive correlation between intrahepatic Breg cells and histological fibrosis stages. Our results suggested that Breg cells may play a role in HBV-related liver cirrhosis, but the function of Breg cells in cirrhosis remains to be further elucidated.
Indexed as
Identifiers
31949852PMC6962989W3006412780What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.