ArticleInternational journal of clinical and experimental pathology2018
Long non-coding RNA Ftx promotes osteosarcoma progression via the epithelial to mesenchymal transition mechanism and is associated with poor prognosis in patients with osteosarcoma.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Prognostic significance of long non-coding RNA five prime to XIST in various cancers.BMC cancer · 2022Pooled it
- Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis.Bioscience reports · 2021Pooled it
- Epithelial-Mesenchymal Transition in Osteosarcoma as a Key Driver of Pulmonary Metastasis.Cancers · 2025Review
- Role of long noncoding RNAs in the regulation of epithelial‑mesenchymal transition in osteosarcoma (Review).Oncology reports · 2025Review
- Emerging roles of long non-coding RNA FTX in human disorders.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Review
- Long noncoding RNA Ftx regulates the protein expression profile in HCT116 human colon cancer cells.Proteome science · 2022Article
- Upregulation of FTX expression is associated with a poor prognosis and contributes to the progression of thyroid cancer.Oncology letters · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLong non-coding RNA Ftx (lncRNA Ftx) is involved in a variety of cancers. However, the association between lncRNA Ftx and osteosarcoma is still unclear. In this study, we investigated the correlation between lncRNA Ftx and osteosarcoma, and the regulative effect of Ftx on the migration and invasion of osteosarcoma cells, as well as its molecular mechanism.
methodsExpression levels of lncRNA Ftx in osteosarcoma tissues and adjacent non-tumor corresponding tissues (ANCTs) were detected using quantitative real-time PCR (qRT-PCR). Differences in patient survival were determined by the Kaplan-Meier method and a log-rank test. The Cox regression analysis was used for univariate and multivariate analyses of prognostic values. Human osteosarcoma cell lines Saos2 and HOS were transfected with the pcDNA-Ftx constructs. The scratch wound healing assay and Transwell assay were used to assess cell migration and invasion capability, respectively. Western blot analysis was conducted to investigate the expression of mesenchymal and epithelial markers.
resultsThe results showed that the lncRNA Ftx group was higher in osteosarcoma tissues compared with the ANCTs group. Expression of lncRNA Ftx was correlated with the clinical stage and distant metastasis (P<0.05). The overall survival rate was lower in the high lncRNA Ftx group than in the low lncRNA Ftx group (log-rank test, P<0.05). Multivariate analysis revealed that in osteosarcoma patients, higher lncRNA MEG3, advanced clinical stage, and distant metastasis were all independent predictors of overall survival. Cell research showed that transfection of lncRNA Ftx significantly promoted the migration and invasion ability of osteosarcoma cells. In addition, E-cadherin was decreased, while N-cadherin and Snail-1 were increased, at both the protein and mRNA levels. Pre-treatment with Snail-1 siRNA abrogated the promotion effect of Ftx on the migration and invasion of osteosarcoma cells.
conclusionsIncreased expression of lncRNA Ftx could not only be a biomarker for progression and prognosis of osteosarcoma, but also could regulate the development of osteosarcoma via the epithelial to mesenchymal transition (EMT) mechanism.
Indexed as
Identifiers
31949847PMC6962994W3011107374What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.