Evidence map›Paper›PMID 31949840›Full record

ArticleInternational journal of clinical and experimental pathology2018

Role of Hsp90/Akt pathway in the pathogenesis of gentamicin-induced hearing loss.

Ruosha Lai, Wei Li, Peng Hu, Dinghua Xie, Jie Wen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Otoprotective Effect of 2,3,4',5-Tetrahydroxystilbene-2-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ruosha LaiDepartment of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, P. R. China.
Wei LiDepartment of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, P. R. China.
Peng HuDepartment of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, P. R. China.
Dinghua XieDepartment of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, P. R. China.
Jie WenDepartment of Pediatric Orthopaedic, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Nomal University Changsha, Hunan, P. R. China.
Central South University · CNHunan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have suggested that gentamicin may induce hair cell apoptosis through the Hsp90/Akt signaling pathway. Nevertheless, the exact mechanisms remain unclear. The following study investigated Hsp90 expression in gentamicin-treated cochleae (

Indexed as

apoptosisgentamicinHair cellshearing lossHsp90

Identifiers

PMID31949840
PMCPMC6962985
OpenAlexW3027424063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.