ArticleInternational journal of clinical and experimental pathology2018
miR-145 regulates the proliferation and apoptosis of Y79 human retinoblastoma cells by targeting IGF-1R.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Insights into retinoblastoma pathogenesis: unraveling RB1, N-MYC and miRNA profiles.BMJ open ophthalmology · 2025Article
- The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells.Cell division · 2025Review
- MicroRNA‑153‑3p suppresses retinoblastoma cell growth and invasion via targeting the IGF1R/Raf/MEK and IGF1R/PI3K/AKT signaling pathways.International journal of oncology · 2021Article
- The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia.Frontiers in cell and developmental biology · 2021Review
- Autophagy-related gene 7 deficiency caused by miR-154-5p overexpression suppresses the cell viability and tumorigenesis of retinoblastoma by increasing cell apoptosis.Annals of translational medicine · 2020Article
- microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma.Clinics (Sao Paulo, Brazil) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of miR-145 on the proliferation and apoptosis of human retinoblastoma Y79 cells and to explore the underlying mechanism.
methodThe Y79 cells were transfected by miR-145 mimics and IGF-1R siRNA with lipofection, respectively. The expression of miR-145 or IGF-1R was detected after transfection by real time-PCR. Cell proliferation inhibition was measured by Cell Counting Kit-8 (CCK-8) assay. Flow cytometry was used to examine cell cycles. Apoptosis was detected by Annexin/PI double immunofluorescence and flow cytometer. The interaction between miR-145 and IGF-1R was tested by luciferase activity measurement.
resultsThe expression of miR-145 in the miR-145 mimics group was significantly increased (
conclusionmiR-145 inhibited proliferation and induced apoptosis in Y79 cells. Lower expression of IGF-1R suppressed the proliferation of Y79 cells. miR-145 restrained the proliferation of human retinoblastoma Y79 cells by down-regulating the expression of IGF-1R.
Indexed as
Identifiers
31949829PMC6962974W3028284096What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.