ReviewInternational journal of clinical and experimental pathology2018
Expression of VEGF, COX-2 and MMP-9 in breast cancer and their relationship with ultrasound findings.
Review in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Chlorogenic acid suppresses angiogenesis in 4T1 breast tumorsResearch in pharmaceutical sciences · 2026Article
- Preoperative ultrasonography-guided core-needle biopsy-based factors for predicting the upgrade of axillary lymph nodes in breast cancer.Quantitative imaging in medicine and surgery · 2025Article
- Efficacy of Pyrotinib combined with Trastuzumab in the treatment of patients with human epidermal growth factor receptor-2 positive breast cancer.Pakistan journal of medical sciences · 2025Article
- Regulation of Matrix Metalloproteinases by Wine-Derived Compounds: Implications for Cancer Therapy.Biomolecules · 2025Review
- Natural Products as Regulators against Matrix Metalloproteinases for the Treatment of Cancer.Biomedicines · 2024Review
- Ultrasound-based radiomics nomogram for predicting axillary lymph node metastasis in invasive breast cancer.American journal of translational research · 2024Article
- Ultrasonography and clinicopathological features of breast cancer in predicting axillary lymph node metastases.BMC cancer · 2022Article
- Prognostic and Immunological Roles of MMP-9 in Pan-Cancer.BioMed research international · 2022Article
- Zinc(II) niflumato complex effects on MMP activity and gene expression in human endometrial cell lines.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe wished to ascertain the relationship between expression of vascular endothelial growth factor (VEGF), cyclo-oxygenase (COX)-2, and matrix metallopeptidase (MMP)-9 and various features of ultrasound images in breast cancer (BC) patients.
methodsEighty-nine breast lesions were confirmed to have BC by ultrasound, surgery and pathology. According to the Breast Imaging Reporting and Data System classification method published by the American College of Radiology, six groups were created: spiculation and non-Burr sign; calcification and non-calcification; vascular anomaly syndrome and non-vascular anomaly syndrome; lymph node metastasis (LNM) and non-LNM. In each case, the expression of VEGF, COX-2 and MMP-9 was detected by immunohistochemistry.
resultsExpression of VEGF, COX-2 and MMP-9 was higher in BC patients with the Burr sign than in those without it (P<0.05). There was no significant difference in expression of VEGF, COX-2, and MMP-9 between the calcification group and non-calcification group of BC patients (P>0.05). Expression of VEGF, COX-2, and MMP-9 was higher in those with vascular abnormalities than in those without them (P<0.05), as well as in the LNM group compared with the non-LNM group (P<0.05).
conclusionsThe high expression of VEGF, COX-2, and MMP-9 could have an influence on the Burr sign, abnormal blood vessels, and LNM in BC patients using ultrasound.
Indexed as
Identifiers
31949822PMC6962978W3027910624What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.