ArticleInternational journal of clinical and experimental pathology2018
Overexpression of FAM3C protein as a novel biomarker for epithelial-mesenchymal transition and poor outcome in gastric cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
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- An integrated study to decipher immunosuppressive cellular communication in the PDAC environment.NPJ systems biology and applications · 2023Article
- FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis.Scientific reports · 2023Article
- FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice.EMBO molecular medicine · 2023Article
- DEK modulates both expression and alternative splicing of cancer‑related genes.Oncology reports · 2022Article
- Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn recent years, overexpression of FAM3C protein has been proved to contribute to epithelial to mesenchymal transition (EMT) and correlate with poor prognosis in several malignant tumors. However, the role of FAM3C in gastric cancer (GC) is still not clear. Thus, we detected the expression of FAM3C by immunohistochemistry (IHC) and determined the association of FAM3C expression with EMT, clinicopathologic characteristics, and prognosis in GC.
methodsWe detected the expression of FAM3C, PDGFR-β, E-cadherin, and vimentin in 150 patients with GC by tissue chip technology and IHC methods. All statistical analyses were conducted using SPSS 22.0 software.
resultsFAM3C expression in gastric carcinoma tissues was significantly higher than in matched adjacent normal tissues (P = 0.037). The expression of FAM3C positively correlated with vimentin expression and negatively correlated with E-cadherin expression (P = 0.045 and 0.029, respectively). However, there was no correlation between expression of FAM3C and PDGFR-β (P = 0.095). FAM3C overexpression was significantly associated with depth of invasion, lymph node metastasis and TNM stage (P = 0.004, 0.016 and 0.022, respectively). Multivariate analysis revealed that high expression of FAM3C is an independent prognostic factor for poor prognosis in GC patients (P = 0.007).
conclusionsOverexpression of FAM3C is a potential marker for EMT and predicts poor outcome in gastric cancer.
Indexed as
Identifiers
31949820PMC6962811W3026839125What OpenQuestion holds
Registered trials
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