Evidence map›Paper›PMID 31949811›Full record

ArticleInternational journal of clinical and experimental pathology2018

Prognostic effect of IL-6/JAK2/STAT3 signal-induced microRNA-21-5p expression on short term recurrence of hepatocellular carcinoma after hepatectomy.

Chengzhan Zhu, Mao Zhang, Jie Hu, Haoran Li, Shihai Liu, Tianxiang Li, Liqun Wu, Bing Han

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chengzhan ZhuDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Mao ZhangDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Jie HuThe Third Xiangya Hospital of Central South University Changsha, Hunan, P. R. China.
Haoran LiDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Shihai LiuMedical Animal Laboratory, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Tianxiang LiDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Liqun WuDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Bing HanDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Qingdao University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the putative role of interleukin (IL)-6/Janus Kinase (JAK) 2/Signal transducers and activators of transcription (STAT) 3 signaling pathway in hepatocellular carcinoma (HCC) short term recurrence (STR), and whether the pathway promotes HCC progression through microRNA-21-5p (miRNA-21).

methodsImmunohistochemistry was performed to evaluate the protein expression of IL-6, JAK2 and STAT3. Real-time PCR was used to evaluate the miRNA-21 expression. We also analyzed the correlation of IL-6, JAK2 and STAT3 protein expression with miRNA-21. Clinicopathological variables, including prognosis, were compared between low and high-expressing groups of miRNA-21.

resultsmiRNA-21 expression was significantly increased in the HCC tumor tissue compared to the non-tumor tissue. IL-6 and STAT3 high expression was significantly correlated to high miRNA-21 expression in HCC tumor tissues. Patients with high miRNA-21 expression have more frequent early recurrence. The 6 month overall survival and disease-free survival rate of the miRNA-21 high groups were 72.1% and 30.8%, respectively. Moreover, high miRNA-21 expression was correlated with disease-free survival (DFS) (P < 0.05) and overall survival (OS) (P < 0.05). Multivariate analysis revealed that miRNA-21 and STAT3 high expression were independent prognostic factors of DFS and OS. The area under the ROC curve (AUC) of miRNA-21 and STR, DFS, OS was 0.951 (P < 0.001), 0.847 (P < 0.001), 0.844 (P < 0.001), respectively.

conclusionsmiRNA-21 expression, induced by IL-6/JAK2/STAT3 signaling pathway, was increased in the early recurrence of HCC patients and indicated poor prognosis. Expression analysis of miRNA-21 revealed that it may be a valuable prognostic biomarker for HCC.

Indexed as

Hepatocellular carcinomaIL-6JAKmicroRNAshort-term recurrenceSTAT

Identifiers

PMID31949811
PMCPMC6962805
OpenAlexW3027791158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.