ArticleInternational journal of clinical and experimental pathology2018
A single nucleotide polymorphism of the interferon-γ gene and susceptibility to hepatitis B virus-related cirrhosis: a randomized controlled trial.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- IFN-γ: A Crucial Player in the Fight Against HBV Infection?Immune network · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the correlation between a single nucleotide polymorphism (SNP) of the interferon-γ (IFN-γ) gene and susceptibility to hepatitis B virus (HBV) -related cirrhosis in the Chinese population.
methodPCR-LDR was employed for the genotyping of two SNPs, rs1861494 and rs2069718, of the IFN-γ gene in 230 patients with HBV-related cirrhosis and 320 inactive HBsAg carriers without cirrhosis. It was then determined whether the Hardy-Weinberg (H-W) equilibrium was satisfied. The odds ratio (OR) and 95% confidence interval (CI) were analyzed using the chi-square test and univariate non-conditional logistic regression. Haplotypes were established using SHEsis and SNPStats online software and their interaction with non-genetic factors was analyzed.
resultsCompared with the AA genotype of rs1861494 SNP, AG+GG genotypes increased the risk of HBV-related cirrhosis. There was a significant difference in the distribution of A and G alleles between the case group and the control group (P<0.05). There was also a significant difference in the distribution of AA, AG, GG, AA, and AG+GG genotypes and A/G alleles between the case group and the control group (P<0.05). This indicated that the G allele may be a risk factor for HBV-related cirrhosis. By analyzing the different distribution of haplotypes in the case group and the control group, we observed significant differences in the distribution of AA, AG and GA haplotypes between the case and control groups (P<0.05). Haplotypes of the IFN-γ gene did not interact with other relevant factors.
conclusionThe G allele of rs1861494 SNP as well as AG and GG genotypes and G allele of rs2069718 SNP may be risk factors of HBV-related cirrhosis. The AA haplotype may be a protective factor for HBV-related cirrhosis, while the AG haplotype is a risk factor for HBV-related cirrhosis.
Indexed as
Identifiers
31949806PMC6962819W3028160771What OpenQuestion holds
Registered trials
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