ArticleInternational journal of clinical and experimental pathology2018
Analysis of human papillomavirus 16 E6/E7 and L1 in the bronchial brushing cells of patients with squamous cell carcinoma of the lungs.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Infection with human cytomegalovirus, Epstein-Barr virus, and high-risk types 16 and 18 of human papillomavirus in EGFR-mutated lung adenocarcinoma.Croatian medical journal · 2023Pooled it
- Interventional bronchoscopy for HPV 16 and 66 with the use of spraying interferon-α (2b) plus bevacizumab and anti-reflux agent.Respiratory medicine case reports · 2021Article
- HPV16 E6/E7 upregulate hTERC mRNA and gene amplification levels by relieving the effect of LKB1 on Sp1 phosphorylation in lung cancer cells.Therapeutic advances in medical oncology · 2020Article
- HPV 16 E6/E7 Promote the Glucose Uptake of GLUT1 in Lung Cancer Through Downregulation of TXNIP Due to Inhibition of PTEN Phosphorylation.Frontiers in oncology · 2020Article
- Human papillomavirus16 E6 but not E7 upregulates GLUT1 expression in lung cancer cells by upregulating thioredoxin expression.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A type of high-risk human papillomavirus (HPV), HPV16 takes part in lung carcinogenesis. E6 and E7 are the major oncoproteins of high-risk HPV, and L1 is the major capsid protein. In this study, we detected their mRNA expressions and analyzed their relationship in the bronchial brushing cells of 211 patients with malignant lesions (squamous cell carcinoma of the lungs) and benign lesions (pneumonia and tuberculosis) by quantitative real-time PCR. HPV16 E6, E7, and L1 mRNA expressions in the malignant group were statistically higher than in benign group (P<0.05), and their mRNA expressions in the squamous cell carcinoma of the lung group were statistically higher than in pneumonia group (P<0.05). There was a negative correlation between L1 and E6 expression in the squamous cell carcinoma of the lungs group (Spearman correlation coefficient r=-0.498, P=0.000). An ROC curve shows that the combination of L1 and E6 is a significant predictor for the diagnosis of squamous cell carcinoma of the lungs (AUC: 0.878; Sensitivity: 96.00%; Specificity: 77.91%), which could make up for the deficiency of cytologic testing. The combined detection of HPV16 E6 and L1 mRNA expressions in bronchial brushing cells by quantitative real-time PCR has a great significance for the diagnosis of squamous cell carcinoma of the lungs, providing new therapeutic targets for the clinical treatment of squamous cell carcinoma of the lungs.
Indexed as
Identifiers
31949804PMC6962774W3026347710What OpenQuestion holds
Registered trials
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