ArticleInternational journal of clinical and experimental pathology2018
Aquaporins 1, 3 and 8 expression and cytokines in irritable bowel syndrome rats' colon via cAMP-PKA pathway.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Electroacupuncture attenuates intervertebral disc degeneration by upregulating aquaporins via the cAMP/PKA pathway.Journal of orthopaedic surgery and research · 2025Article
- A set of downregulated pleiotropic genes are possible multi-omics biomarkers underlying the irritable bowel syndrome-non-alcoholic fatty liver disease comorbidity.American journal of translational research · 2025Article
- Study on the effect of 3,5,6,7,8,3',4'-heptamethoxyflavone inFrontiers in pharmacology · 2025Article
- The Role of Long Noncoding RNAs in Intestinal Health and Diseases: A Focus on the Intestinal Barrier.Biomolecules · 2023Review
- The Role of Ion Channels in Functional Gastrointestinal Disorders (FGID): Evidence of Channelopathies and Potential Avenues for Future Research and Therapeutic Targets.International journal of molecular sciences · 2023Review
- New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics.Journal of gastroenterology · 2023Review
- Protein Structure and Modification of Aquaporins.Advances in experimental medicine and biology · 2023Article
- Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induced by GPR109A.International journal of molecular sciences · 2022Article
- The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier.BioMed research international · 2021Review
- LncRNA H19 as a Competing Endogenous RNA to Regulate AQP Expression in the Intestinal Barrier of IBS-D Patients.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIrritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders. The cAMP-PKA pathway plays a key role in mediating cell responses to various stimuli both of which might play an important role in IBS.
objectiveOur research aimed to detect the mechanism of IBS rat models via the cAMP-PKA pathway so as to further detect the mechanisms of IBS.
methodsIBS rats were built by stress and conditioned stimulus. The study was divided into 3 groups (a control group, a model group, and a forskolin group). The expressions of AQP1, AQP3, AQP8, and CREB (Serl33) in the colons of rats were detected by immunohistochemistry. The expressions of AQP1, AQP3, AQP8, IL-1β, TGF β, and TNF α in the colon were detected by the PCR technique.
resultsThe IBS rats were built successfully. The expressions of AQP1, AQP3, AQP8, and CREB (Serl33) were down-regulated in the colons of IBS rats and were up-regulated with the intervention of the activator of AMP (P<0.05). The expressions of IL-1β, TGF β and TNF α were up-regulated in the colons of IBS rats and were down-regulated with the intervention of the activator of AMP (P<0.05).
conclusionsThe release of inflammatory cytokines, the activation of the immune system and liquid water metabolic abnormalities are the mechanisms of IBS via the cAMP-PKA pathway.
Indexed as
Identifiers
31949803PMC6962796W3028008840What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.