Evidence map›Paper›PMID 31949778›Full record

ArticleInternational journal of clinical and experimental pathology2018

Genome-wide SNP and InDel mutations in Mycobacterium tuberculosis associated with rifampicin and isoniazid resistance.

Haicheng Li, Huixin Guo, Tao Chen, Li Yu, Yuhui Chen, Jiao Zhao, Huimin Yan, Mu Chen, Qi Sun, Chenchen Zhang and 2 more

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. First-line drug resistance profiling ofAMIA ... Annual Symposium proceedings. AMIA Symposium · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Haicheng LiReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Huixin GuoReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Tao ChenReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Li YuReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Yuhui ChenOutpatient Office Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Jiao ZhaoMedical College of Jinan University Guangzhou China.
Huimin YanGuangdong Medical University Dongguan, China.
Mu ChenDepartment of Pulmonology, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou, China.
Qi SunReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Chenchen ZhangReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Lin ZhouReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Liang ChenReference Laboratory, Centre for Tuberculosis Control of Guangdong Province Guangzhou, China.
Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMultiple resistances to isoniazid and rifampicin lead to the majority of death associated with

methodsThe

resultsTotally 58 nonsynonymous SNP mutations, 64 synonymous SNP mutations, and 99 SNP mutations in intergenic regions were detected in

conclusionBy whole genome sequencing, many genetic mutations in both known and new genes associated with isoniazid and rifampicin resistance were characterized in

Indexed as

drug resistanceInDel mutationisoniazidMycobacterium tuberculosisrifampicinSNP

Identifiers

PMID31949778
PMCPMC6962771
OpenAlexW3027718114

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.