ArticleInternational journal of clinical and experimental pathology2018
The association between surfactant protein B gene variation and bronchopulmonary dysplasia in Chinese premature newborns.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors at 2 institutions in 1 country.
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Abstract
objectiveThis study aimed to correlate the pulmonary surfactant B (SP-B) gene variation with bronchopulmonary dysplasia (BPD) in ethnic Han, Chinese, premature newborns.
method47 newborns with BPD and 55 controls without BPD were included. Genomic DNA was extracted from cord or artery blood. Genotyping for the SP-B gene was performed by polymerase chain reaction or gene sequencing, and the clinical characteristics were also analyzed.
resultsTwo types of SP-B gene variations in Exon 2 or Exon 5 were discovered, including V1 (Exon 2: c.[5A > C] + [5A > C] or c.[5A > C] + [=]) and V2 (Exon 5: c.[428C > T] + [428C > T] or c.[428C > T] + [=]). In the BPD group, there were 33 newborns with gene variations, of which type V1 and V2 accounted for 18 and 15 respectively. In the control group, there were 19 newborns with gene variations, of which type V1 and V2 accounted for 7 and 12 respectively. There was a significant difference between the two groups in type V1 variation (X
conclusionsThe exon 2 or 5 of SP-B gene variations were associated with the BPD in Chinese premature newborns, and the type V1: Exon 2: c.[5A > C] + [5A > C] or c.[5A > C] + [=] was a risk factor for the development of BPD.
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31949759PMC6962831W3026741161What OpenQuestion holds
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