ArticleInternational journal of clinical and experimental pathology2018
Expression of glucose transporter-1, hypoxia inducible factor-1α and beclin-1 in head and neck cancer and their implication.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Prognostic Utility of Autophagy Marker Beclin1 in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Head and neck pathology · 2025Pooled it
- The Molecular Basis and Biomarker Potential of the HIF-1α-VEGF-GLUT1 Hypoxia Axis in Laryngeal Squamous Cell Carcinoma.Biomedicines · 2026Review
- Prognostic Value of Beclin-1 and HIF-1α in Oral Squamous Cell Carcinoma.European journal of dentistry · 2026Article
- Tumor hypoxia and role of hypoxia-inducible factor in oral cancer.World journal of surgical oncology · 2024Review
- Assessment of the association of OCT3/4 with GLUT1 and CD105 in oral squamous cell carcinoma using dual immunohistochemistry.BMC oral health · 2022Observational
- Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice.International journal of molecular sciences · 2022Article
- 3,4‑Dihydroxyacetophenone attenuates oxidative stress‑induced damage to HUVECs via regulation of the Nrf2/HO‑1 pathway.Molecular medicine reports · 2022Article
- Glucose transporters: Important regulators of endometrial cancer therapy sensitivity.Frontiers in oncology · 2022Review
- Effect of GLUT1 Inhibition and Autophagy Modulation on the Growth and Migration of Laryngeal Carcinoma Stem Cells Under Hypoxic and Low-Glucose Conditions.OncoTargets and therapy · 2021Article
- Autophagy-Related Beclin 1 and Head and Neck Cancers.OncoTargets and therapy · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that oncogenes, tumor suppressor genes, and hypoxic factors are involved in the pathogenesis, development, and progression of head and neck cancer. In this study, we investigated the expression of HIF-1α, GLUT-1, and beclin-1 in head and neck cancers and analyzed the relationship between these markers and clinicopathologic factors. 44 paraffin-embedded samples of head and neck cancer specimens were collected. The expression of HIF-1α, GLUT-1, Ki 67, and beclin-1 was detected by immunohistochemical technique. The expression of HIF-1α, GLUT-1, Ki 67, and beclin-1 in head and neck cancers were higher than those for the corresponding paracancerous tissues. Stratification analysis revealed a significant difference between GLUT-1 expression in older patients with laryngeal/hypopharyngeal SCC and younger patients with laryngeal/hypopharyngeal SCC. No significant differences in GLUT-1 or beclin-1 or HIF-1α or Ki 67 expression were found between clinicopathologic characteristics, including lymph node metastasis, T stage, clinical stage, and location, for any of the cancer types studied. Pearson analysis revealed that there was a negative correlation between beclin-1 and HIF-1α (r=0.482, P=0.001), and between beclin-1 and Ki-67 (r=-0.366, P=0.0151). Whether beclin-1 plays a role in carcinogenesis in head and neck cancers should be further studied.
Indexed as
Identifiers
31949754PMC6962823W2951603910What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.