Expression of vimentin and Oct-4 in gallbladder adenocarcinoma and their relationship with vasculogenic mimicry and their clinical significance.

Vimentin (a marker of epithelial-mesenchymal transition), and Oct-4 (a marker of cancer stem cells) are predicative biomarkers for identifying malignant cell invasion and metastasis. Vasculogenic mimicry (VM), a newly discovered tumor characteristic that is common in highly invasive malignancies, is considered to be an important factor in evaluating the prognosis and metastasis of many malignancies. The following paper analyzes the correlation between vimentin, Oct-4, and VM in gallbladder adenocarcinoma (GBAC) specimens using immunohistochemistry in an attempt to elucidate the survival and clinicopathological parameters of changes in vimentin, Oct-4, and VM. Briefly, significantly higher positive expression rates of vimentin, Oct-4, and VM were observed in GBAC tissues than in the corresponding para-carcinoma tissues. In addition, the levels of vimentin, Oct-4, and VM were positively correlated with tumor grade, lymph node metastasis (LNM), infiltration of the surrounding tissues (STI), and tumor-node-metastasis (TNM) stage, as well as inversely with a patient's overall survival (OS) time. Moreover, the analysis of multiple factors shows that high vimentin, Oct-4, and VM levels, STI, and LNM as well as TNM stage were potential and significant factors for OS time in patients with GBAC. To sum up, the positive expression of vimentin, Oct-4, and VM may be undesirable factors for metastasis, invasion and prognosis, as well as effective therapeutic targets for GBAC.