ArticleInternational journal of clinical and experimental pathology2018
HPP1 gene promoter methylation in pancreatic cancer: correlation with carcinogenesis and clinical implication.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- DNA methylation and miR-92a-3p-mediated repression of HIP1R promotes pancreatic cancer progression by activating the PI3K/AKT pathway.Journal of cellular and molecular medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant methylation of the promoter region in a tumor suppressor gene is a significant early event in carcinogenesis of pancreatic cancer. Methylation status of a tumor suppressor gene may be useful as a diagnostic marker for early detection of pancreatic cancer. The current study evaluated methylation status of the hyperplastic polyposis 1 (HPP1) gene transcriptional regulation region (TRR) in pancreatic cancer and normal tissue samples by bisulfite-specific PCR (BSP) cloningbased sequencing analysis and quantitative methylationspecific PCR (qMSP). Correlation of methylation with the clinicopathological characteristics of the pancreatic cancer patients was also assessed. The results demonstrated that the HPP1 promoter was significantly hypermethylated in the pancreatic cancer tissues compared with normal tissues and a significant correlation between HPP1 methylation level and tumor-node-metastasis stage was observed. Thus, our study suggests that methylation of the HPP1 gene is a potential clinically diagnostic and prognostic biomarker for pancreatic cancer.
Indexed as
Identifiers
31949740PMC6962862W3026777787What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.