ArticleInternational journal of clinical and experimental pathology2018
Overexpression of PTP4A1 is associated with poor overall survival in non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- PTP4A1 promotes intrahepatic cholangiocarcinoma development and progression by interacting with PTEN and activating the PI3K/AKT/GSKα axis.Oncology reports · 2025Article
- PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming.Cell death discovery · 2023Article
- GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1.Molecular medicine reports · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to analyze the phosphatases of regenerating liver 1 (PTP4A1) expression and its relationship with tumor invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC).
methodsThe retrospective study enrolled 150 cases who underwent radical resection for primary NSCLC during the period from January 2006 to January 2014. Baseline characteristics of patients included age, gender, smoking history, pathological type, histological grade, clinical stage, and lymphatic metastasis. Lung cancer tissues collected from 150 cases and precancerous tissues, and normal lung tissues collected from 20 cases were used for PTP4A1 detection by immunohistochemistry.
resultsThe expression of PTP4A1 was significantly different in different tissue samples (P = 0.025). The expression level of PTP4A1 was associated with clinical stage (P = 0.022), and lymphatic metastasis (P = 0.011). Survival analysis showed the total survival rate of overexpressed PTP4A1 group was significantly lower than that of the low expressed PTP4A1 group (P = 0.006), while the recurrence rate of overexpressed PTP4A1 was significantly higher than that of the low expressed PTP4A1 group (P = 0.014). In addition, the OS was affected by lymphatic metastasis, and disease-free survival was influenced by pathological type and lymphatic metastasis.
conclusionThe PTP4A1 expression level is a potential prognostic biomarker for NSCLC, and overexpression of PTP4A1 suggested a high risk of poor DFS during follow-up. Also, lymphatic metastasis had an adverse effect on survival time.
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31949737PMC6962830W3027501415What OpenQuestion holds
Registered trials
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