ArticleInternational journal of clinical and experimental pathology2018
AFP-negative mixed hepatoid adenocarcinoma of the colon: a case report with review of literature.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mixed epithelial endocrine neoplasms of the colon and rectum - An evolution over time: A systematic review.World journal of gastroenterology · 2020Pooled it
- A case report of two instances of colorectal hepatoid adenocarcinoma, accompanied by a comprehensive literature review.Journal of cancer research and clinical oncology · 2023Review
- Mediastinal Hepatoid Adenocarcinoma Treated With Arterial Interventional Therapy: A Case Report and Review of Literature.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the clinicopathologic profile of hepatoid adenocarcinoma (HAC) of the colon and to improve the diagnostic and treatment level. MATERIALS AND
methodsThe clinical observations and histopathologic and immunohistochemical features of HAC were analyzed.
resultsHAC is usually composed of well-differentiated common adenocarcinoma and hepatoid differentiation. The tumor cells in hepatoid differentiation area are arranged in trabecular or solid shape, with large polygonal tumor cells, and abundant cytoplasm. Immunohistochemical markers showed the HAC cells were positive for Glypican-3, HepPar1, CK19, and carcinoembryonic antigen (CEA), while alpha-fetoprotein (AFP) was negative.
conclusionHAC is a rare malignant tumor of the colon. Its diagnosis depends on histopathology and immunohistochemical staining. Surgical resection should be the treatment of choice if possible.
Indexed as
Identifiers
31949708PMC6962827What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.