ArticleInternational journal of clinical and experimental pathology2018
Angiogenin negatively regulates the expression of basic fibroblast growth factor (bFGF) and inhibits bFGF promoter activity.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Review
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research focused on angiogenin and basic fibroblast growth factor (bFGF) was expected to identify means to inhibit tumor growth and metastasis. However, interactions exist between the two angiogenic factors, and the overall mechanism is still not clear. To explore the mechanism by which angiogenin regulates the expression of bFGF, RT-PCR and western blot were performed to analyze bFGF expression. Nuclear translocation of angiogenin was investigated by immunofluorescence staining and immune electron microscopy. Site-directed mutagenesis, reporter gene assays, and electrophoretic gel mobility shift assay (EMSA) were applied to investigate the promoter activity. The results showed that angiogenin negatively regulates bFGF expression in HeLa cells. Angiogenin undergoes nuclear translocation, and an angiogenin binding site (CTCTCTCT) on the bFGF promoter was identified. bFGF promoter activity was inhibited by angiogenin. Angiogenin and bFGF are two potent and representative angiogenesis factors, that play an important role in tumor angiogenesis and development. These mechanisms guide us to further investigate the effect of angiogenin and bFGF on tumor growth and development.
Indexed as
Identifiers
31949702PMC6962887W3028503430What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.