ArticleInternational journal of clinical and experimental pathology2018
The overexpression of PDGF-BB and its receptor is correlated with lymphatic metastasis in patients with non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review).Molecular medicine reports · 2026Review
- Advances in lymphatic metastasis of non-small cell lung cancer.Cell communication and signaling : CCS · 2024Review
- Lymphangiogenesis: A new strategy for heart disease treatment (Review).International journal of molecular medicine · 2024Review
- Differential cytokine and chemokine expression after ablation vs. resection in colorectal cancer liver metastasis.Surgery open science · 2024Article
- PDGFBB facilitates tumorigenesis and malignancy of lung adenocarcinoma associated with PI3K-AKT/MAPK signaling.Scientific reports · 2024Article
- Overexpression of Platelet-Derived Growth Factor and Its Receptor Are Correlated with Oral Tumorigenesis and Poor Prognosis in Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metastasis of tumors through lymphatic vessels is an important adverse prognostic factor for human cancers. Non-small cell lung cancer (NSCLC) is one of the most common types of lung cancers, and usually occurs with metastasis at an early stage and has a poor prognosis. Lymphatic metastasis is the most common route of lung cancer metastasis, and it requires the interaction of multiple growth factors. Platelet-derived growth factor-BB (PDGF-BB) and platelet-derived growth factor receptor-β (PDGFR-β) are related to both angiogenesis and lymphangiogenesis. This study aimed to explore PDGF-BB/PDGFR-β and its correlations with lymphatic microvessel density (LMVD) and lymph node metastasis in patients with non-small cell lung cancer (NSCLC). A total of 127 Chinese patients with NSCLC pathologically diagnosed from 2009 to 2013 were enrolled in the study. The expression levels of PDGF-BB and PDGFR-β were measured in all NSCLC tissues using immunohistochemical staining. Further, LMVD stained by D2-40 was evaluated, and the platelet (PLT) count was determined. The expression levels of PDGF-BB and PDGFR-β in the NSCLC tissues were 73.2% (93/127) and 78.0% (99/127) respectively in 127 patients. The expressions of PDGF-BB and PDGFR-β and LMVD were associated with TNM stage, lymph node metastasis, and PLT (
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Identifiers
31949689PMC6963076W3004499637What OpenQuestion holds
Registered trials
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