ArticleInternational journal of clinical and experimental pathology2018
Expression of miR-9 in the serum of patients with acute ischemic stroke and its effect on neuronal damage.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- The Relationship Between Clinical Features of Ischemic Stroke and miRNA Expression in Stroke Patients: A Systematic Review.Neurology international · 2025Review
- Considering Context-Specific microRNAs in Ischemic Stroke with Three "W": Where, When, and What.Molecular neurobiology · 2024Review
- Role of transcription factors, noncoding RNAs, epitranscriptomics, and epigenetics in post-ischemic neuroinflammation.Journal of neurochemistry · 2024Review
- Differential Expression of Serum TUG1, LINC00657, miR-9, and miR-106a in Diabetic Patients With and Without Ischemic Stroke.Frontiers in molecular biosciences · 2021Article
- Long noncoding RNA HULC in acute ischemic stroke: Association with disease risk, severity, and recurrence-free survival and relation with IL-6, ICAM1, miR-9, and miR-195.Journal of clinical laboratory analysis · 2020Article
- Long Non-Coding RNA SNHG7 Alleviates Oxygen and Glucose Deprivation/Reoxygenation-Induced Neuronal Injury by Modulating miR-9/SIRT1 Axis in PC12 Cells: Potential Role in Ischemic Stroke.Neuropsychiatric disease and treatment · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis research was aimed to measure the expression of miR-9 in serum of acute ischemic stroke (AIS) patients and explore the role of miR-9 on OGD-induced neuronal damage.
methodsIn the present study, we measured the expression of miR-9 in serum of 65 AIS patients by real-time quantitative PCR (RT-qPCR) and the effect of miR-9 on oxygen-glucose deprivation (OGD)-induced neuronal injury was detected by CCK-8 in vitro. Western blot was used to measure the expression of protein.
resultsWe found that the serum level of miR-9 in 65 AIS patients was significantly higher than that in control group (no-AIS), and was positively correlated with NIHSS score (r=0.627, P<0.001), infarct volume ((r=0.576, P<0.001), serum IL-8 (r=0.376, P=0.002), TNF-α (r=0.418, P<0.001), IL-6 (r=0.545, P<0.001), and IL-1β (r=0.592, P<0.001). miR-9 expression levels were upregulated in cultured neurons with OGD treatment. The downregulation of miR-9 significantly alleviated OGD-induced neuronal injury. Dual-luciferase reporter assay demonstrated that SIRT1 was a target gene of miR-9, and miR-9 negatively regulated SIRT 1 expression and positively regulated p65 expression.
conclusionsAll in all, our data showed that downregulation of miR-9 protected neurons against OGD/R-induced injury by the SIRT1-mediated NF-kB pathway.
Indexed as
Identifiers
31949675PMC6963079W3005106846What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.