ArticleInternational journal of clinical and experimental pathology2018
Expression of NF-κB and TLR-4 is associated with the occurrence, progression and prognosis of esophageal squamous cell carcinoma.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- The Prognostic Value of Toll-Like Receptors in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2020Pooled it
- Review
- Gut microbiota-cholesterol crosstalk in cardiovascular diseases: mechanisms, metabolites, and therapeutic modulation.Nutrition & metabolism · 2025Review
- Exosome-mediated lnc-ABCA12-3 promotes proliferation and glycolysis but inhibits apoptosis by regulating the toll-like receptor 4/nuclear factor kappa-B signaling pathway in esophageal squamous cell carcinoma.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Apoptosis and Cell Proliferation Markers in Inflammatory-Fibroproliferative Diseases of the Vessel Wall (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Article
- Systemic Delivery of siRNA Specific for Silencing TLR4 Gene Expression Reduces Diabetic Cardiomyopathy in a Mouse Model of Streptozotocin-Induced Type 1 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a crucial regulator of inflammation and immune responses, the NF-κB transcription factor regulates the transcription of target genes which are closely related with cell survival, cell proliferation, apoptosis, invasion and metastasis. The toll-like receptor (TLR) family is critical in aiding pathogen recognition and the subsequent activation of innate immunity. TLR4, one of the TLR family members, is the main receptor of innate immunity and functions to identify pathogens. However, the significance of the expressions of both NF-κB and TLR-4 in the occurrence, development and prognosis of esophageal squamous cell carcinoma (ESCC) remains unclear.
methodsNF-κB and TLR-4 expressions were analyzed in tissue microarrays made up of low grade intraepithelial neoplasia (LGIN), high grade intraepithelial neoplasia (HGIN), early-stage ESCC, advanced ESCC tissue samples, as well as normal healthy esophageal mucosa. Chi-squared tests and Kaplan-Meier plots were utilized to determine the prognostic values of the NF-κB and TLR-4 expressions.
resultsWe discovered that NF-κB and TLR-4 expressions were progressively increasing from normal esophageal mucosa, LGIN, HGIN and were highest in early-stage ESCC. Interestingly, TLR-4 and NF-κB expressions were attenuated in advanced ESCC tissue. Suppressed expressions of TLR-4 and NF-κB correlated to increasingly malignant ESCC. Additionally, there was a positive correlation between NF-κB and TLR-4 expressions.
conclusionTLR-4 and NF-κB are associated with the occurrence, development and malignant evolution of ESCC.
Indexed as
Identifiers
31949671PMC6963060W3009461379What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.