ArticleInternational journal of clinical and experimental pathology2018
LncRNA CERNA2 is an independent predictor for clinical prognosis and is related to tumor development in gastric cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies.Scientific reports · 2024Article
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- Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials.Bioengineering (Basel, Switzerland) · 2022Review
- Upregulation of long noncoding RNA W42 promotes tumor development by binding with DBN1 in hepatocellular carcinoma.World journal of gastroenterology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) is the second most common cancer-related mortality worldwide. Mounting evidence has demonstrated that dysregulated long noncoding RNAs (lncRNAs) are involved in the development of GC. LncRNA CERNA2 (competing endogenous lncRNA 2 for microRNA let-7b) was previously found to be upregulated and play an oncogenic role in hepatocellular carcinoma, osteosarcoma and breast cancer. However, the clinical significance and biological functions of CERNA2 in GC remain largely unknown. In this study, we found that CERNA2 expression was significantly increased in GC tissues and cell lines compared to adjacent non-cancerous tissues and normal gastric epithelial cells, respectively. High levels of CERNA2 were correlated with poor clinical parameters and an unfavorable prognosis of GC patients. Moreover, silencing CERNA2 expression effectively inhibited gastric cancer cell growth and induced cell apoptosis
Indexed as
Identifiers
31949664PMC6963070W3007311248What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.