ArticleInternational journal of clinical and experimental pathology2018
WDR1 predicts poor prognosis and promotes cancer progression in hepatocellular carcinoma.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Systematic pan-cancer analysis reveals context-dependent prognostic and immunological roles of WDR1 with divergent effects in renal and gastric cancers.Frontiers in immunology · 2026Article
- WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling.Medical oncology (Northwood, London, England) · 2024Article
- Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer.American journal of cancer research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
WDR1, an activator of cofilin-mediated actin depolymerization, is involved in various actin-dependent processes of living cells including cell migration and cytokinesis. Recently, several studies have found that WDR1 is dysregulated in several types of cancer and is associated with cancer metastasis. However, its role in hepatocellular carcinoma (HCC) remains unknown. In this study, we found that WDR1 expression was aberrantly upregulated at the mRNA and protein levels in HCC cell lines and HCC tissues. WDR1 overexpression was highly correlated with tumor aggressive phenotypes such as capsulation formation, microvascular invasion (MVI), tumor node metastasis (TNM) stage, and was an independent poor prognostic factor for overall survival (OS) and disease-free survival (DFS) for HCC patients after curative surgery. Furthermore, WDR1 overexpression significantly promoted HCC cell migration, invasion and proliferation. In contrast, WDR1 downregulation inhibited HCC cell migration, invasion and proliferation. Conclusion: This study indicates that WDR1 could be used as a new useful prognostic marker and may be a potential therapeutic target for HCC.
Indexed as
Identifiers
31949654PMC6963092W3007146447What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.