ArticleInternational journal of clinical and experimental pathology2018
Perfluorooctanoic acid exposure during pregnancy alters the apoptosis of uterine cells in pregnant mice.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid.Experimental and therapeutic medicine · 2023Article
- Risk to human health related to the presence of perfluoroalkyl substances in food.EFSA journal. European Food Safety Authority · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigates the effects of perfluorooctanoic acid (PFOA) exposure on reproductive toxicity and uterine apoptosis in pregnant mice. Sixty pregnant mice were randomly divided into 6 groups (groups A, B, C, D, E and F). In control group (A), the mice received distilled water at 10 mg/kg body weight per day on gestation days (GD) 1 to 17. The mice in group B, C, D, E and F were treated with PFOA solution at 1, 5, 10, 20 and 40 mg/kg body weight respectively from GD1 to GD17. The mice were sacrificed on GD18. The distribution and expression of Fas, FasL, Bcl-2, Bax, and Caspase-3 in uterine cells were detected by immunohistochemistry. The apoptosis of uterine cells was detected by TdT-mediated dUTP Nick-End Labeling (TUNEL). Results showed that the expression of Fas, FasL, and Caspase 3 in uterus increased significantly after PFOA was applied. The expression of Bcl-2 was decreased significantly and the expression of Bax was increased significantly. The ratio of Bcl-2/Bax decreased significantly compared with the control group (P<0.01). PFOA exposure increased the number of apoptotic uterine cells in a dose-dependent manner. The results indicated that PFOA could accelerate the apoptosis of uterine cells, and lead to slow embryo development or abortion by regulating the expression of Fas, FasL, Bax, Bcl-2 and Caspase-3 in uterine cells.
Indexed as
Identifiers
31949647PMC6963104W3028567233What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.