ArticleInternational journal of clinical and experimental pathology2018
Circulating GRP78 acts as a biomarker in the early diagnosis of lung cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review).International journal of molecular medicine · 2026Review
- Inhibition of cell surface GRP78 on brain tumors reverses drug resistance and stops cancer stem cell expansion.The Journal of biological chemistry · 2026Article
- The relationship between serum levels of GRP78, GRP94, calnexin, and calreticulin and prognosis in patients with lung cancer.Cancer biomarkers : section A of Disease markers · 2025Article
- Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target.Frontiers in oncology · 2024Review
- COVID-19, Obesity, and GRP78: Unraveling the Pathological Link.Journal of obesity & metabolic syndrome · 2023Review
- GRP78, a Novel Host Factor for SARS-CoV-2: The Emerging Roles in COVID-19 Related to Metabolic Risk Factors.Biomedicines · 2022Review
- Induction of ER Stress by an AAV5 BDD FVIII Construct Is Dependent on the Strength of the Hepatic-Specific Promoter.Molecular therapy. Methods & clinical development · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose-regulated protein 78 (GRP78) is a major chaperone in endoplasmic reticulum (ER) and is increased in many types of malignant tumors. The role of GRP78 in early lung cancer diagnosis has not been clearly reported. The aim of this study is to detect the circulating level of GRP78 in the plasma of lung cancer patients and to evaluate the role of GRP78 in the early diagnosis of lung cancer. Plasma was collected from 251 lung cancer patients and 105 healthy controls, and the GRP78 expression in each sample was assayed using a commercially available ELISA kit. A receiver operating characteristic curve (ROC curve) was performed to analyze the role of GRP78 in lung cancer diagnosis. The combination of GRP78 and CEA, Cyfra21-1 was then analyzed using SPSS 17.0. The circulating level of GRP78 was increased dramatically in lung cancer patients (P < 0.0001) compared with the healthy controls. GRP78 provided a more sensitive and specific diagnosis than CEA in all lung cancer, ADC, and SCC patients, as well as in early (stage I) lung cancer patients. The results also indicated that a combination of GRP78, CEA and Cyfra21-1 could increase the accuracy of lung cancer diagnosis. GRP78 could be used as circulating biomarker in early lung cancer diagnosis.
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Identifiers
31949602PMC6963050W3026506035What OpenQuestion holds
Registered trials
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