Intrathyroid thymic carcinoma: report of two cases with pathologic and immunohistochemical studies.

Yan-Hua Sun, Juan Xu, Ming Li

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In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yan-Hua SunDepartment of Pathology, Shenzhen Second People's Hospital, Sun Yat-sen University Shenzhen, Guangdong Province, PR China.

Juan XuDepartment of Pharmacology and Proteomics Center, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou, Guangdong Province, PR China.

Ming LiDepartment of Immunology, College of Basic Medical Science, Central South University Changsha, Hunan, PR China.

Central South University · CNShenzhen Second People's Hospital · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrathyroid thymic carcinoma (ITCA) is a rare neoplasm of the thyroid gland, that is difficult to diagnose because of its complex pathologic and immunohistochemical characteristics. Here, we report two cases that may provide a better understanding of this disease. Case 1 is a 30-year-old man, and Case 2 is a 42-year-old man. The two cases showed an irregular solid thyroid mass on sonography. Histological examination revealed the solid growth of epithelial cells separated by bands of dense, hyalinized, and fibrous stroma. Tumor cells were positive for the expression of CD5, HMWK, CK19, CK5/6, CK7, EMA, CD117, p63, Bcl-2, and NANOG. It is noteworthy that the neuroendocrine markers Syn, NSE, and CgA were also observed. In Case 1, chemotherapy combined with radiotherapy, chest CT showed lung metastasis 4 months after resection. The patient was alive as of postoperative follow up lasting 46 months. Radical operation combined with radiotherapy was performed in case 2, and the patient was alive as of follow-up lasting 42 months.

Indexed as

histopathologyneuroendocrine markerspathologic diagnosisThyroid neoplasm

Identifiers

PMID31949593

PMCPMC6962924

OpenAlexW3028137353

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.