ArticleInternational journal of clinical and experimental pathology2018
Relationship of SNP rs35767 in IGF-1 promoter region with susceptibility to colorectal cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- A systematic review and meta-analysis for the association of the insulin-like growth factor1 pathway genetic polymorphisms with colorectal cancer susceptibility.Frontiers in oncology · 2023Pooled it
- Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study.Discover oncology · 2024Article
- The Insulin-like Growth Factor System and Colorectal Cancer.Life (Basel, Switzerland) · 2022Review
- Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study.BMC nephrology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro and animal experiments demonstrate that IGF-1 appears to play a role in the development and growth of colorectal cancer and the function of free IGF-1 protein is mediated by IGF-1R. The IGF-1R system plays a critical role in promoting the normal development of cells and malignant transformation via the phosphatidylinositol 3-kinase (PI3)/AKTA and mitogen-activated protein kinase (MAPK) pathways. Different variants of the promoter of IGF-1 are involved in the risk of suffering from various diseases. The current study examined the relationship between IGF-1 rs35767 polymorphism and the risk of colorectal cancer (CRC) in a population from China. The genotypes of rs35767 polymorphism of the promoter region of IGF-1 were examined in 734 subjects: 367 patients with CRC and 367 healthy individuals by PCR. LDL and TC levels in colorectal cancer patients were significantly higher than those in the healthy control group (
Indexed as
Identifiers
31949589PMC6962907W3028432238What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.