ArticleInternational journal of clinical and experimental pathology2018
LPS induces dopamine depletion and iron accumulation in substantia nigra in rat models of Parkinson's disease.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- In vivo Effects of Acute Inflammatory Responses on Dopaminergic Receptor Expression in Leukocytes and Marginal Effects of Hypoxia Pretreatment.Neuroimmunomodulation · 2026Article
- Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration.Nature communications · 2024Article
- Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.Redox biology · 2024Review
- Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use.Molecules (Basel, Switzerland) · 2022Review
- Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIntrapallidal inflammation may lead to the pathogenesis of Parkinson's disease. Pathological changes caused by lipopolysaccharide (LPS)-induced inflammation in Parkinson's disease rat models were largely unknown.
methodsMale Sprague-Dawley rat models were intra-globuspallidus injected with saline and lipopolysaccharide and divided into two groups, the control group and the LPS-stimulation group. The locomotor activity of the rat models was recorded for 4 consecutive weeks by trajectory analysis software for animal behavior. For the evaluation of pathological profiles, the expression levels of tyrosine hydroxylase and OX-42 in the substantia nigra tissues were detected by immunohistochemical staining. Also, the concentrations of dopamine at specific sites were detected through high-performance liquid chromatography. Perl's iron staining was used to evaluate iron accumulation in substantia nigra tissues.
resultsLPS-stimulation reduced the locomotor capacity of the rat models compared with the control group. The density of tyrosine hydroxylase-positive cells was reduced and the secretion of striatal dopamine in the substantia nigra pars compacts was lower in the LPS group than it was in the control group. OX-42 positive microglia and ferritin levels were enhanced in the LPS group.
conclusionIntrapallidal inflammation by LPS induced dopamine depletion and iron accumulation in the substantia nigra of Parkinson's disease rat models. The management of cerebral inflammation might be pivotal for PD pathogenesis and prognosis.
Indexed as
Identifiers
31949570PMC6962913W3010537490What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.