ArticleThe Indian journal of radiology & imaging
Hyperglycemia-induced seizures - Understanding the clinico- radiological association.
Article in The Indian journal of radiology & imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
- Diabetic striatopathy and concurrent peri-ictal cortical diffusion restriction in nonketotic hyperglycemia: A rare stroke mimic.Radiology case reports · 2026Article
- Reversible Cortical Visual Symptoms of Hyperosmolar Hyperglycemic State May Occur in Patients with Borderline Serum Osmolality.Neuro-ophthalmology (Aeolus Press) · 2026Article
- Article
- Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats.Synapse (New York, N.Y.) · 2025Article
- Non-ketotic Hyperglycemia Presenting as Focal Status Epilepticus and Subsequent Todd's Paralysis.Cureus · 2024Article
- Case Report: Abruptio placentae and epileptic seizure after occurrence of perinatal hyperglycaemia in woman with gestational diabetes mellitus and hypertriglyceridemia-induced acute pancreatitis.Frontiers in endocrinology · 2023Article
- GM3 synthase deficiency increases brain glucose metabolism in mice.Molecular genetics and metabolism · 2022Article
- T2-FLAIR Hypointense White Matter Signal in Non-Ketotic Hyperglycemic Seizures.The Neurohospitalist · 2022Article
- Fresh Cerebral Infarction-Like MRI Findings Mimicking Hyperosmolar Hyperglycemic Syndrome With Seizures.Cureus · 2022Article
- Recurrent Facial Focal Seizures With Chronic Striatopathy and Caudate Atrophy-A Double Whammy in an Elderly Woman With Diabetes Mellitus.The Neurohospitalist · 2022Article
- Epileptic seizures during Non-Ketotic Hyperglycemia (NKH) in French Guiana: A retrospective study.Frontiers in endocrinology · 2022Observational
- Magnetic resonance imaging findings in patients with non-ketotic hyperglycaemia and focal seizures.The neuroradiology journal · 2020Article
- Article
- Hyperglycemia-induced seizures and blindness.The Indian journal of radiology & imagingArticle
- Reply to: The dark side of T2: central nervous system lesions with low signal intensity on T2-weighted imaging.Radiologia brasileiraArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo highlight the typical magnetic resonance imaging (MRI) findings in hyperglycemia-induced seizures and compare the results with similar previous studies with a brief mention of pathophysiological mechanisms. MATERIALS AND
methodsThis retrospective study included medical and imaging records of six consecutive patients with hyperglycemia-induced seizures. The data analysis included a clinical presentation and biochemical parameters at admission. The MRI sequences were evaluated for region involved, presence of subcortical T2 hypo-intensity, cortical hyper-intensity, and restricted diffusion. Similar previous studies from the National Library of Medicine (NLM) were analyzed and compared with our study.
resultsTwenty-four patients were included from four studies in previous literature for comparison. In our study, on imaging, posterior cerebral region was predominantly involved, with parietal involvement in 83.3%, followed by occipital, frontal, and temporal involvement in 33.3% patients compared with occipital in 58.3%, parietal in 45.8%, and frontal and temporal in 16.6% of patients in previous literature. The subcortical T2 hypo-intensity was present in 83.3% of the patients, cortical hyper-intensity in all patients, and restricted diffusion in 66.6% of the patients in our study compared with subcortical T2 hypo-intensity in 95.8% of the patients, cortical hyper-intensity in 62.5%, and restricted diffusion in 58.3% of the patients in previous literature.
conclusionAlthough many etiologies present with subcortical T2 hypointensity, cortical hyperintensity, restricted diffusion, and postcontrast enhancement on MRI, the clinical setting of seizures in a patient with uncontrolled hyperglycemia, hyperosmolar state, and absence of ketones should suggest hyperglycemia-induced seizures to avoid misdiagnosis, unnecessary invasive investigations, and initiate timely management. ADVANCES IN KNOWLEDGE: Our study highlights the presence of posterior predominant subcortical T2, fluid-attenuated inversion recovery (FLAIR), and susceptibility-weighted angiography (SWAN) hypointensity; cortical hyperintensity; and restricted diffusion in hyperglycemia-induced seizures. The presence of T2 and SWAN hypointensity could support the hypothesis of possible deposition of free radicals and iron in the subcortical white matter.
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