Evidence map›Paper›PMID 31949277›Full record

ArticleScientific reports2020

Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq).

Yuanyuan Zheng, Taiyu Hui, Chang Yue, Jiaming Sun, Dan Guo, Suling Guo, Suping Guo, Bojiang Li, Zeying Wang, Wenlin Bai

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

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  11. Identification and Molecular Analysis of mAnimals : an open access journal from MDPI · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yuanyuan ZhengCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Taiyu HuiCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Chang YueCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Jiaming SunCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Dan GuoLiaoning Modern Agricultural Production Base Construction Engineering Center, Liaoyang, 111000, China.
Suling GuoProsperous Community, Changshun Town, Huade, 013350, China.
Suping GuoCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Bojiang LiCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Zeying WangCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. wangzeying2012@syau.edu.cn.
Wenlin BaiCollege of Animal Science &Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. baiwenlin@syau.edu.cn.
Shenyang Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) is endogenous non-coding RNA (ncRNA) with a covalently closed circular structure. It is mainly generated through RNA alternative splicing or back-splicing. CircRNA is known in the majority of eukaryotes and very stable. However, knowledge of the circRNA involved in regulating cashmere fineness is limited. Skin samples were collected from Liaoning cashmere goats (LCG) and Inner Mongolia cashmere goats (MCG) during the anagen period. For differentially expressed circRNAs, RNA sequencing was performed, and the analysis led to an identification of 17 up-regulated circRNAs and 15 down-regulated circRNAs in LCG compared with MCG skin samples. In order to find the differentially expressed circRNAs in LCG, we carried out qPCRs on 10 candidate circRNAs in coarse type skin of LCG (CT-LCG) and fine type skin of LCG (FT-LCG). Four circRNAs: ciRNA128, circRNA6854, circRNA4154 and circRNA3620 were confirmed to be significantly differential expression in LCG. Also, a regulatory network of circRNAs-miRNAs was bioinformatically deduced and may help to understand molecular mechanisms of potential circRNA involvement in regulating cashmere fineness.

Indexed as

AnimalsComputational BiologyFemaleGene Expression RegulationGene Regulatory NetworksGoatsHigh-Throughput Nucleotide SequencingMicroRNAsRNA, CircularSequence Analysis, RNASkinMicroRNAsRNA, Circular

Identifiers

PMID31949277
PMCPMC6965140
OpenAlexW3003645905

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.