ArticleScientific reports2020
Sleep disturbance in Inflammatory Bowel Disease: prevalence and risk factors - A cross-sectional study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Systematic review: Individual-level factors and social determinants of health impacting sleep health in individuals with inflammatory bowel disease.Journal of advanced nursing · 2023Pooled it
- A temporal dialogue between the circadian clock and chronic inflammatory diseases.Disease models & mechanisms · 2026Review
- Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease.Experimental physiology · 2026Article
- Advancing therapeutic frontiers: a pipeline of novel drugs for UC management.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis.Frontiers in immunology · 2026Article
- Sleep quality and associated factors in patients with inflammatory bowel disease: a cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Pain and Sedative Medication Use Among Individuals With Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study.Alimentary pharmacology & therapeutics · 2025Article
- Article
- Association between gastrointestinal disorders and sleep-related problems: the mediating effect of depression.BMC gastroenterology · 2025Article
- Multimodal Lifestyle Intervention Improves Fatigue in Quiescent Inflammatory Bowel Disease: A Controlled Study.Crohn's & colitis 360 · 2025Article
- Evaluation of inflammatory bowel disease-related sleep disorders based on an interpretable machine learning approach: a multicenter study in China.Therapeutic advances in gastroenterology · 2025Article
- Poor sleep quality is common and independently associated with disease activity and poor quality of life in inflammatory bowel disease: a long-term follow-up study.Therapeutic advances in gastroenterology · 2025Article
- Subjective and objective sleep quality assessment in adolescent patients with inflammatory bowel disease.Sleep medicine: X · 2024Article
- The influence of sleep factors and dietary habits on the disease pattern of ulcerative colitis patients with long and short disease courses - a multicentre cross-sectional analysis.Annals of medicine · 2024Article
- Prevalence and risk factors of sleep disorders in inflammatory bowel disease: a cross-sectional study.International journal of colorectal disease · 2024Article
- Active Inflammatory Bowel Disease Is Associated with Short Sleep Duration via Objective Measures.Digestive diseases and sciences · 2024Observational
- Home parenteral nutrition, sleep patterns, and depressive symptoms: Secondary analysis of cross-sectional data.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study.United European gastroenterology journal · 2024Article
- Impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population-based cohort study.BMJ open · 2024Observational
- Impact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans.BMC gastroenterology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel diseases (IBD) are chronic relapsing disorders that have a negative impact on quality of life. They can be highly disabling and have been associated with sleep disturbance. The aim of our study was to evaluate the sleep quality of a large cohort of IBD patients to identify possible associated cofactors. We prospectively recruited consecutive patients attending the IBD Unit of "Azienda Ospedaliera" of Padua from November 2018 to May 2019 and collected demographics and clinical characteristics. The patients completed the Pittsburgh Sleep Quality Index (PSQI), the IBD questionnaire (IBDQ), the IBD-Disability Index (IBD-DI) questionnaire, and the Hospital Anxiety and Depression Scale (9-HADS). A multivariate regression model was applied to assess independent risk factors of sleep disturbance among IBD-related variables, disability, quality of life, anxiety, and depression. We investigated the sleep quality of 166 patients with IBD, finding 67.5% of them suffering from sleep disturbance. In particular, low quality of life, presence of disability and extraintestinal manifestations were identified as independent risk factors of sleep disturbance. We discovered that all depressed patients were also affected by sleep disturbance, while we found no difference in sleep disturbance between patients with or without anxiety state. However, a positive correlation was reported between both anxiety and depression scores and PSQI score (Spearman correlation: r = 0.31 and r = 0.38 respectively). Our study showed that sleep quality is not directly associated with an active or inactive IBD state or with the ongoing treatment, but it is mostly correlated with the patients' mood state, disability, and quality of life. Gastroenterologists and psychologists should join forces during clinical outpatients' visits to evaluate emotional states for a better IBD management.
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