Evidence map›Paper›PMID 31949163›Full record

ReviewNature reviews. Disease primers2020

Autism spectrum disorder.

Catherine Lord, Traolach S Brugha, Tony Charman, James Cusack, Guillaume Dumas, Thomas Frazier, Emily J H Jones, Rebecca M Jones, Andrew Pickles, Matthew W State and 2 more

Erratum issued 5 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 5 registered trials, which are not on this map. Cited by 904 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
904citing papers in PubMed, 7 pooled it
89.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05359757 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Naturalistic Teaching Strategies in Children With Autism Spectrum Disorder

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled19ConditionsAutism Spectrum DisorderArmsEffect of Naturalistic Teaching Strategies in Children with autism spectrum disorder, PECS Therapy only
NCT05475132 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Exergaming on Bimanual Hand Dexterity in Autistic Children

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2023Enrolled20ConditionsAutism Spectrum DisorderArmsExergaming, Conventional Dexterity Exercises
NCT06512649 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2026Enrolled48ConditionsNeurodevelopmental Disorders, Autism Spectrum DisorderArmsEarly intervention, Active monitoring
NCT06673732 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Muscle Energy Technique With and Without Stationary Cycling on Toe Walking With Autism Spectrum Disorder.

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled26ConditionsAutism Spectrum DisorderArmsMuscle Energy Technique with Stationary Bi-Cyclying, Muscle Energy Technique without Stationary Cycling
NCT07061119 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Cawthorne Cooksey Exercises on Balance in Autistic Children With Vestibular Hypofunction.

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled44ConditionsAutism Spectrum Disorder, Vestibular HypofunctionArmsConventional treatment, cawthorne cooksey exercises
3 · Its place in the literature

Who cites it

904 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,571 citations in OpenAlex.

  1. Pooled it
  2. Autistic Traits and Camouflaging: A Meta-Analysis.Autism : the international journal of research and practice · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

844 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 3 countries.

Catherine LordDepartments of Psychiatry and School of Education, University of California, Los Angeles, Los Angeles, CA, USA. clord@mednet.ucla.edu.
Traolach S BrughaDepartment of Health Sciences, University of Leicester, Leicester, UK.
Tony CharmanInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
James CusackAutistica, London, UK.
Guillaume DumasInstitut Pasteur, UMR3571 CNRS, Université de Paris, Paris, France.
Thomas FrazierAutism Speaks, New York, NY, USA.
Emily J H JonesCentre for Brain & Cognitive Development, University of London, London, UK.
Rebecca M JonesThe Sackler Institute for Developmental Psychobiology, New York, NY, USA.
Andrew PicklesInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Matthew W StateDepartment of Psychiatry, Langley Porter Psychiatric Institute and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Julie Lounds TaylorDepartment of Pediatrics and Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeremy Veenstra-VanderWeeleDepartment of Psychiatry, Columbia University, New York, NY, USA.
King's College London · GBAutism360 · USAutism Speaks · USAutistica · GBColumbia University · USUniversité Paris Cité · FRUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Leicester · GBUniversity of London · GBVanderbilt University Medical Center · US

Funding

The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order PhenotypesU01MH115747 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN, KROGAN, NEVAN J · 2018 to 2022
$19.6M
Translational Research Training in Child PsychiatryT32MH016434 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Cristiane S. Duarte, Kate Dimond Fitzgerald · 1985 to 2026
$10.9M
Functional Genomics of Human Brain DevelopmentP50MH106934 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2019
$7.9M
2/3-Identifying regulatory mutations that influence neuropsychiatric diseaseU01MH105575 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STATE, MATTHEW W. · 2014 to 2018
$5.7M
Improving Transition Outcomes for Youth with Autism through Parent Advocacy Training: A Multi-State Randomized Controlled TrialR01MH116058 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TAYLOR, JULIE LOUNDS · 2019 to 2023
$4.1M
Transitioning to Adulthood: A Prospective Longitudinal StudyR01HD081199 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2015 to 2019
$3.1M
Longitudinal Studies of Autism Spectrum Disorders: 2 to 23R01MH081873 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORD, CATHERINE · 2008 to 2012
$2.7M
Integrating the genomics of Autism Spectrum Disorders(ASD) in consanguineous and "idiopathic" familiesR01MH102342 · NIMH · YALE UNIVERSITY · PI GUNEL, MURAT, STATE, MATTHEW W. · 2015 to 2018
$2.4M
Neurobiological Signatures of Social Dysfunction and Repetitive BehaviorR01MH094604 · NIMH · VANDERBILT UNIVERSITY · PI VEENSTRA-VANDERWEELE, JEREMY · 2011 to 2015
$2.0M
Data-driven multidimensional modeling of nonverbal communication in typical and atypical developmentR01MH114999 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI ROZGA, AGATA · 2018 to 2022
$1.8M
4/4 - The Autism Sequencing Consortium: Autism Gene Discovery in >50,000 ExomesU01MH111662 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SANDERS, STEPHAN, STATE, MATTHEW W. · 2017 to 2021
$1.3M
3/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SANDERS, STEPHAN, STATE, MATTHEW W. · 2016 to 2019
$1.3M
Medical Research Council MR/K021389/1Medical Research Council MR/T003057/1NICHD NIH HHS R01 HD081199NIMH NIH HHS P50 MH106934NIMH NIH HHS R01 MH081873NIMH NIH HHS R01 MH094604NIMH NIH HHS R01 MH102342NIMH NIH HHS R01 MH109901NIMH NIH HHS R01 MH110928NIMH NIH HHS R01 MH114999NIMH NIH HHS R01 MH116058NIMH NIH HHS R03 MH112783NIMH NIH HHS R34 MH104428NIMH NIH HHS T32 MH016434NIMH NIH HHS U01 MH105575NIMH NIH HHS U01 MH111662NIMH NIH HHS U01 MH115747
6 · The paper itself

Abstract

Autism spectrum disorder is a construct used to describe individuals with a specific combination of impairments in social communication and repetitive behaviours, highly restricted interests and/or sensory behaviours beginning early in life. The worldwide prevalence of autism is just under 1%, but estimates are higher in high-income countries. Although gross brain pathology is not characteristic of autism, subtle anatomical and functional differences have been observed in post-mortem, neuroimaging and electrophysiological studies. Initially, it was hoped that accurate measurement of behavioural phenotypes would lead to specific genetic subtypes, but genetic findings have mainly applied to heterogeneous groups that are not specific to autism. Psychosocial interventions in children can improve specific behaviours, such as joint attention, language and social engagement, that may affect further development and could reduce symptom severity. However, further research is necessary to identify the long-term needs of people with autism, and treatments and the mechanisms behind them that could result in improved independence and quality of life over time. Families are often the major source of support for people with autism throughout much of life and need to be considered, along with the perspectives of autistic individuals, in both research and practice.

Indexed as

Autism Spectrum DisorderHumansQuality of LifeSex Characteristics

Identifiers

PMID31949163
PMCPMC8900942
OpenAlexW2769544142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.