Evidence map›Paper›PMID 31949156›Full record

ArticleNature communications2020

Edible unclonable functions.

Jung Woo Leem, Min Seok Kim, Seung Ho Choi, Seong-Ryul Kim, Seong-Wan Kim, Young Min Song, Robert J Young, Young L Kim

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Covert Optical Fingerprints Within Overt Structural Colors via Cascaded Cavity Resonances.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Designing Physical Unclonable Functions From Optically Active Materials.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Nanoscale Silicon Fingerprints for Counterfeit Prevention in Microchips.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jung Woo LeemWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.ORCID http://orcid.org/0000-0001-5008-2356
Min Seok KimSchool of Electrical Engineering and Computer Science, Gwangju Institute of Science Technology, Gwangju, 61005, Republic of Korea.ORCID http://orcid.org/0000-0003-2614-9607
Seung Ho ChoiDepartment of Biomedical Engineering, Yonsei University, Wonju, 26493, Republic of Korea.
Seong-Ryul KimDepartment of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
Seong-Wan KimDepartment of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
Young Min SongSchool of Electrical Engineering and Computer Science, Gwangju Institute of Science Technology, Gwangju, 61005, Republic of Korea.
Robert J YoungDepartment of Physics, Lancaster University, Lancaster, LA1 4YB, UK.
Young L KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA. youngkim@purdue.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Counterfeit medicines are a fundamental security problem. Counterfeiting medication poses a tremendous threat to patient safety, public health, and the economy in developed and less developed countries. Current solutions are often vulnerable due to the limited security levels. We propose that the highest protection against counterfeit medicines would be a combination of a physically unclonable function (PUF) with on-dose authentication. A PUF can provide a digital fingerprint with multiple pairs of input challenges and output responses. On-dose authentication can verify every individual pill without removing the identification tag. Here, we report on-dose PUFs that can be directly attached onto the surface of medicines, be swallowed, and digested. Fluorescent proteins and silk proteins serve as edible photonic biomaterials and the photoluminescent properties provide parametric support of challenge-response pairs. Such edible cryptographic primitives can play an important role in pharmaceutical anti-counterfeiting and other security applications requiring immediate destruction or vanishing features.

Indexed as

Consumer Product SafetyCounterfeit DrugsDeveloping CountriesDrug IndustryDrug UtilizationGreen Fluorescent ProteinsHumansPublic HealthCounterfeit DrugsGreen Fluorescent Proteins

Identifiers

PMID31949156
PMCPMC6965141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.