ArticleNature communications2020
Holographic detection of nanoparticles using acoustically actuated nanolenses.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Improved acoustic holograms using simulated annealing.Biomicrofluidics · 2025Article
- Unsupervised Learning-Assisted Acoustic-Driven Nano-Lens Holography for the Ultrasensitive and Amplification-Free Detection of Viable Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Acoustography by Beam Engineering and Acoustic Control Node: BEACON.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Programmable Acoustic Holography using Medium-Sound-Speed Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Intelligent nanoscope for rapid nanomaterial identification and classification.Lab on a chip · 2022Article
- Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation.Microsystems & nanoengineering · 2022Article
- Advancing the science of dynamic airborne nanosized particles using Nano-DIHM.Communications chemistry · 2021Article
- Conventional and microfluidic methods for airborne virus isolation and detection.Colloids and surfaces. B, Biointerfaces · 2021Review
- Diagnosis of Herpes Simplex Virus: Laboratory and Point-of-Care Techniques.Infectious disease reports · 2021Review
- Development of a Point-of-Care Assay for HIV-1 Viral Load Using Higher Refractive Index Antibody-Coated Microbeads.Sensors (Basel, Switzerland) · 2021Article
- High-Precision Lensless Microscope on a Chip Based on In-Line Holographic Imaging.Sensors (Basel, Switzerland) · 2021Article
- Article
- Detection of Bacterial and Viral Pathogens Using Photonic Point-of-Care Devices.Diagnostics (Basel, Switzerland) · 2020Review
- Single-shot 3D wide-field fluorescence imaging with a Computational Miniature Mesoscope.Science advances · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The optical detection of nanoparticles, including viruses and bacteria, underpins many of the biological, physical and engineering sciences. However, due to their low inherent scattering, detection of these particles remains challenging, requiring complex instrumentation involving extensive sample preparation methods, especially when sensing is performed in liquid media. Here we present an easy-to-use, high-throughput, label-free and cost-effective method for detecting nanoparticles in low volumes of liquids (25 nL) on a disposable chip, using an acoustically actuated lens-free holographic system. By creating an ultrasonic standing wave in the liquid sample, placed on a low-cost glass chip, we cause deformations in a thin liquid layer (850 nm) containing the target nanoparticles (≥140 nm), resulting in the creation of localized lens-like liquid menisci. We also show that the same acoustic waves, used to create the nanolenses, can mitigate against non-specific, adventitious nanoparticle binding, without the need for complex surface chemistries acting as blocking agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.