Evidence map›Paper›PMID 31949127›Full record

ArticleCell death & disease2020

ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD.

Fangfang Cai, Huangru Xu, Nini Cao, Xiangyu Zhang, Jia Liu, Yanyan Lu, Jia Chen, Yunwen Yang, Jian Cheng, Zi-Chun Hua and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Hydrogen Sulfide Metabolism in the Skin: From Physiology to Malignancy.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. FADD as a key molecular player in cancer progression.Molecular medicine (Cambridge, Mass.) · 2022
    Review
  13. Article
  14. Synthesis of 4,5-Dihydro-1Molecules (Basel, Switzerland) · 2022
    Article
  15. Hydrogen Sulfide Suppresses Skin Fibroblast ProliferationOxidative medicine and cellular longevity · 2022
    Article
  16. The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Role of hydrogen sulfide donors in cancer development and progression.International journal of biological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fangfang CaiThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Huangru XuThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Nini CaoThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Xiangyu ZhangThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Jia LiuThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Yanyan LuThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Jia ChenThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Yunwen YangThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.
Jian ChengInstitute of Neuroscience, Soochow University, Suzhou, China. jiancheng8@hotmail.com.
Zi-Chun HuaThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China. hzc1117@nju.edu.cn.
Hongqin ZhuangThe State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China. hqzhuang@nju.edu.cn.
Nanjing University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen sulfide (H

Indexed as

Up-RegulationAnimalsApoptosisCarcinogenesisCell Line, TumorCell ProliferationDown-RegulationFas-Associated Death Domain ProteinHumansHydrogen SulfideMelanoma, ExperimentalMice, Inbred C57BLNerve Tissue ProteinsProteolysisRibonucleoproteinsThiones5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thioneFas-Associated Death Domain ProteinHydrogen SulfideMakorin ring finger protein 1Nerve Tissue ProteinsRibonucleoproteinsThionesUbiquitin

Identifiers

PMID31949127
PMCPMC6965651
OpenAlexW2999520210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.