Evidence map›Paper›PMID 31949118›Full record

ArticleThe European respiratory journal2020

Genetic susceptibility to asthma increases the vulnerability to indoor air pollution.

Anke Hüls, Aneesa Vanker, Diane Gray, Nastassja Koen, Julia L MacIsaac, David T S Lin, Katia E Ramadori, Peter D Sly, Dan J Stein, Michael S Kobor and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
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  8. Article
  9. Childhood Air Pollution Exposure Associated with Self-reported Bronchitic Symptoms in Adulthood.American journal of respiratory and critical care medicine · 2024
    Article
  10. Review
  11. Article
  12. Air pollution and pregnancy.Seminars in perinatology · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023
    Review
  17. Article
  18. Holy Grail: the journey towards disease modification in asthma.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Anke HülsDepts of Epidemiology and Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA anke.huels@emory.edu.ORCID 0000-0002-6005-417X
Aneesa VankerDept of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
Diane GrayDept of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
Nastassja KoenDept of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Julia L MacIsaacCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
David T S LinCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Katia E RamadoriCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Peter D SlyChildren's Health and Environment Program, Child Health Research Centre, The University of Queensland, Brisbane, Australia.
Dan J SteinDept of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7218-7810
Michael S KoborCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Heather J ZarDept of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and South African Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
South African Medical Research Council · ZAUniversity of British Columbia · CAChildren's Medical Research Institute · AU

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
NIEHS NIH HHS P30 ES019776Wellcome Trust 204755/Z/16/Z
6 · The paper itself

Abstract

introductionIndoor air pollution and maternal smoking during pregnancy are associated with respiratory symptoms in infants, but little is known about the direct association with lung function or interactions with genetic risk factors. We examined associations of exposure to indoor particulate matter with a 50% cut-off aerodynamic diameter of 10 µm (PM

methodsData from the Drakenstein Child Health Study, a South African birth cohort, were analysed (n=270). Lung function was measured at 6 weeks and 1 year of age, and lower respiratory tract infection episodes were documented. We measured pre- and postnatal PM

resultsPre- and postnatal exposure to PM

conclusionsPM

Indexed as

Air PollutantsAir PollutionAir Pollution, IndoorAsthmaChildFemaleGenetic Predisposition to DiseaseHumansInfantParticulate MatterPregnancyAir PollutantsParticulate Matter

Identifiers

PMID31949118
PMCPMC7931665
OpenAlexW2999200431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.