Evidence map›Paper›PMID 31949110›Full record

ArticleThe European respiratory journal2020

Culture of pulmonary artery endothelial cells from pulmonary artery catheter balloon tips: considerations for use in pulmonary vascular disease.

Corey E Ventetuolo, Jason M Aliotta, Julie Braza, Havovi Chichger, Mark Dooner, Donald McGuirl, Christopher J Mullin, Julie Newton, Mandy Pereira, Amy Princiotto and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Lung endothelial cell heterogeneity in health and pulmonary vascular disease.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Circulation research · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Corey E VentetuoloDept of Medicine, Brown University, Providence, RI, USA corey_ventetuolo@brown.edu.
Jason M AliottaDept of Medicine, Brown University, Providence, RI, USA.
Julie BrazaVascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Havovi ChichgerBiomedical Research Group, Dept of Biomedical and Forensic Sciences, Anglia Ruskin University, Cambridge, UK.
Mark DoonerLifespan Hospital System, Providence, RI, USA.
Donald McGuirlTufts University School of Medicine, Boston, MA, USA.
Christopher J MullinDept of Medicine, Brown University, Providence, RI, USA.
Julie NewtonVascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Mandy PereiraLifespan Hospital System, Providence, RI, USA.
Amy PrinciottoVascular Research Laboratory, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Peter J QuesenberryDept of Medicine, Brown University, Providence, RI, USA.
Thomas WalshLifespan Hospital System, Providence, RI, USA.ORCID 0000-0003-2620-6843
Mary WhittenhallDept of Medicine, Brown University, Providence, RI, USA.
James R KlingerDept of Medicine, Brown University, Providence, RI, USA.
Elizabeth O HarringtonDept of Medicine, Brown University, Providence, RI, USA.
Brown University · USProvidence College · USProvidence VA Medical Center · USAnglia Ruskin University · GBTufts University · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
TYORISINE PHOSPHATASE SHP2 IN HEMATOPOIETIC STEM CELL PROPERTY MAINTENANCEP20RR025179 · NCRR · RHODE ISLAND HOSPITAL · PI YANG, WENTIAN · 2009 to 2011
$6.4M
Effects of DHEA in Pulmonary Hypertension (DiPH)R01HL141268 · NHLBI · RHODE ISLAND HOSPITAL · PI VENTETUOLO, COREY E · 2018 to 2022
$3.7M
NCRR NIH HHS P20 RR025179NHLBI NIH HHS R01 HL141268NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

Endothelial dysfunction is a hallmark of pulmonary arterial hypertension (PAH) but there are no established methods to study pulmonary artery endothelial cells (PAECs) from living patients. We sought to culture PAECs from pulmonary artery catheter (PAC) balloons used during right-heart catheterisation (RHC) to characterise successful culture attempts and to describe PAEC behaviour.PAECs were grown in primary culture to confluence and endothelial cell phenotype was confirmed. Standard assays for apoptosis, migration and tube formation were performed between passages three to eight. We collected 49 PAC tips from 45 subjects with successful PAEC culture from 19 balloons (39%).There were no differences in subject demographic details or RHC procedural details in successful

Indexed as

Pulmonary ArteryVascular DiseasesCathetersCells, CulturedEndothelial CellsHumansLung

Identifiers

PMID31949110
PMCPMC7147989
OpenAlexW2999471208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.