ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Differences in Frontal Network Anatomy Across Primate Species.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- Evolution of the frontal aslant tract and implications for primate vocalization and human speech.Nature communications · 2026Article
- Comparing the Limbic-Frontal Connectome across the Primate Order: Conservation of Connections and Implications for Translational Neuroscience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Microsurgical anatomy of the anterior commissure with special emphasis on the anterior limb: a comparative white matter fiber microdissection and tractography study.Brain structure & function · 2025Article
- Evidence for an Evolutionary Continuity in Social Dominance: Insights from Nonhuman Primate Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Animal models are useful in studying human neuroanatomy with tractography.Brain structure & function · 2025Article
- Cross-species neuroanatomy in primates using tractography.Brain structure & function · 2025Review
- The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy.Brain : a journal of neurology · 2025Review
- Associations of white matter hyperintensity with frailty, sarcopenia, and nutritional risk: an analysis of an acute ischemic stroke patient database.Frontiers in medicine · 2025Article
- Investigating the role of the left inferior frontal gyrus in language evolution: insights from comparative neuroscience.Frontiers in human neuroscience · 2025Review
- Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates.eLife · 2024Article
- Timescales of learning in prefrontal cortex.Nature reviews. Neuroscience · 2024Review
- Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human.Communications biology · 2024Article
- Why did humans surpass all other primates? Are our brains so different? Part 2.Dementia & neuropsychologia · 2024Review
- Neurobiological mechanisms for language, symbols and concepts: Clues from brain-constrained deep neural networks.Progress in neurobiology · 2023Review
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
- Architecture and connectivity of the human angular gyrus and of its homolog region in the macaque brain.Brain structure & function · 2023Review
- Article
- A connectomics-based taxonomy of mammals.eLife · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 7 countries.
Funding
Abstract
The frontal lobe is central to distinctive aspects of human cognition and behavior. Some comparative studies link this to a larger frontal cortex and even larger frontal white matter in humans compared with other primates, yet others dispute these findings. The discrepancies between studies could be explained by limitations of the methods used to quantify volume differences across species, especially when applied to white matter connections. In this study, we used a novel tractography approach to demonstrate that frontal lobe networks, extending within and beyond the frontal lobes, occupy 66% of total brain white matter in humans and 48% in three monkey species: vervets (Chlorocebus aethiops), rhesus macaque (Macaca mulatta) and cynomolgus macaque (Macaca fascicularis), all male. The simian-human differences in proportional frontal tract volume were significant for projection, commissural, and both intralobar and interlobar association tracts. Among the long association tracts, the greatest difference was found for tracts involved in motor planning, auditory memory, top-down control of sensory information, and visuospatial attention, with no significant differences in frontal limbic tracts important for emotional processing and social behaviour. In addition, we found that a nonfrontal tract, the anterior commissure, had a smaller volume fraction in humans, suggesting that the disproportionally large volume of human frontal lobe connections is accompanied by a reduction in the proportion of some nonfrontal connections. These findings support a hypothesis of an overall rearrangement of brain connections during human evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.