ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Infant Cortical Tracking of Speech Shows Emerging Spatial Release from Masking in the First Year of Life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Infant cortical tracking of speech shows emerging spatial release from masking in the first year of life.bioRxiv : the preprint server for biology · 2026Article
- Oligodendrocyte arrangement, identification and morphology in the developing superior olivary complex.Frontiers in cellular neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Developmental fine-tuning of medial superior olive neurons mitigates their predisposition to contralateral sound sources.PLoS biology · 2024Article
- Comparative transcriptome analysis provides insights into the molecular mechanisms of high-frequency hearing differences between the sexes of Odorrana tormota.BMC genomics · 2022Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
- Ambient noise exposure induces long-term adaptations in adult brainstem neurons.Scientific reports · 2021Article
- Arrangement of Excitatory Synaptic Inputs on Dendrites of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Minimal Number of Required Inputs for Temporally Precise Action Potential Generation in Auditory Brainstem Nuclei.Frontiers in cellular neuroscience · 2020Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The development of sensory circuits is partially guided by sensory experience. In the medial superior olive (MSO), these refinements generate precise coincidence detection to localize sounds in the azimuthal plane. Glycinergic inhibitory inputs to the MSO, which tune the sensitivity to interaural time differences, undergo substantial structural and functional refinements after hearing onset. Whether excitation and calcium signaling in the MSO are similarly affected by the onset of acoustic experience is unresolved. To assess the time window and mechanism of excitatory and calcium-dependent refinements during late postnatal development, we quantified EPSCs and calcium entry in MSO neurons of Mongolian gerbils of either sex raised in a normal and in an activity altered, omnidirectional white noise environment. Global dendritic calcium transients elicited by action potentials disappeared rapidly after hearing onset. Local synaptic calcium transients decreased, leaving a GluR2 lacking AMPAR-mediated influx as the only activity-dependent source in adulthood. Exposure to omnidirectional white noise accelerated the decrease in calcium entry, leaving membrane properties unaffected. Thus, sound-driven activity accelerates the excitatory refinement and shortens the period of activity-dependent calcium signaling around hearing onset. Together with earlier reports, our findings highlight that excitation, inhibition, and biophysical properties are differentially sensitive to distinct features of sensory experience.
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