ArticleLearning & memory (Cold Spring Harbor, N.Y.)2020
Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Sex-specific circadian and behavioral phenotypes in aged growth hormone receptor knockout mice.GeroScience · 2026Article
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- Growth hormone is required for hippocampal engram cell maturation.Science advances · 2025Article
- Article
- Assessment of Executive Function Skills in Children with Isolated Growth Hormone Deficiency: A Cross-sectional StudyJournal of clinical research in pediatric endocrinology · 2024Article
- Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain.Acta pharmacologica Sinica · 2023Article
- The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis.Frontiers in endocrinology · 2023Review
- Research progress on the role of hormones in ischemic stroke.Frontiers in immunology · 2022Review
- An exercise "sweet spot" reverses cognitive deficits of aging by growth-hormone-induced neurogenesis.iScience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging and in endocrine disorders. Several brain areas express receptors for GH although their functional role is unclear. To determine how GH affects the capacity for learning and memory by specific actions in one of the key areas, the hippocampus, we injected recombinant adeno-associated viruses (rAAVs) in male rats to express green fluorescent protein (GFP) combined with either GH, antagonizing GH (aGH), or no hormone, in the dorsal CA1. We found that aGH disrupted memory in the Morris water maze task, and that aGH treated animals needed more training to relearn a novel goal location. In a one-trial spontaneous location recognition test, the GH treated rats had better memory performance for object locations than the two other groups. Histological examinations revealed that GH increased the dendritic spine density on apical dendrites of CA1, while aGH reduced the spine density. GH increased the relative amount of immature spines, while aGH decreased the same amount. Our results imply that GH is a neuromodulator with strong influence over hippocampal plasticity and relational memory by mechanisms involving modulation of dendritic spines. The findings are significant to the increasing aging population and GH deficiency patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.