Evidence map›Paper›PMID 31949004›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.

Mihajlo Novakovic, Gregory L Olsen, György Pintér, Daniel Hymon, Boris Fürtig, Harald Schwalbe, Lucio Frydman

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Unmasking DNA Resonances by Suppression of Hyperpolarized Water.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA.Journal of the American Chemical Society · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Inversion of HyperpolarizedThe journal of physical chemistry. B · 2022
    Article
  14. Article
  15. Article
  16. Parahydrogen-Induced Polarization of Amino Acids.Angewandte Chemie (International ed. in English) · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER.Angewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mihajlo NovakovicDepartment of Chemical and Biological Physics, Weizmann Institute of Science, 76100 Rehovot, Israel.
Gregory L OlsenDepartment of Chemical and Biological Physics, Weizmann Institute of Science, 76100 Rehovot, Israel.ORCID 0000-0001-6039-8434
György PintérInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, D-60438 Frankfurt/Main, Germany.
Daniel HymonInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, D-60438 Frankfurt/Main, Germany.
Boris FürtigInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, D-60438 Frankfurt/Main, Germany.ORCID 0000-0001-6443-7656
Harald SchwalbeInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, D-60438 Frankfurt/Main, Germany schwalbe@nmr.uni-frankfurt.de lucio.frydman@weizmann.ac.il.ORCID 0000-0001-5693-7909
Lucio FrydmanDepartment of Chemical and Biological Physics, Weizmann Institute of Science, 76100 Rehovot, Israel; schwalbe@nmr.uni-frankfurt.de lucio.frydman@weizmann.ac.il.ORCID 0000-0001-8208-3521
Goethe University Frankfurt · DEWeizmann Institute of Science · ILUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NMR sensitivity-enhancement methods involving hyperpolarized water could be of importance for solution-state biophysical investigations. Hyperpolarized water (HyperW) can enhance the

Indexed as

Aptamers, NucleotideImino AcidsNuclear Magnetic Resonance, BiomolecularRiboswitchRNARNA FoldingWaterAptamers, NucleotideImino AcidsRiboswitchRNAWaterhyperpolarized NMRnuclear magnetic resonanceriboswitch refoldingRNA structuresensitivity enhancement

Identifiers

PMID31949004
PMCPMC7007528
OpenAlexW3000566802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.