Evidence map›Paper›PMID 31948901›Full record

ArticleSchizophrenia research2020

Associations between physiological responses to social-evaluative stress and daily functioning in first-episode schizophrenia.

Alexandra C Reed, Junghee Lee, Michael F Green, Holly K Hamilton, Gregory A Miller, Kenneth L Subotnik, Joseph Ventura, Keith H Nuechterlein, Cindy M Yee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alexandra C ReedDepartment of Psychology, University of California, Los Angeles, Franz Hall, 502 Portola Plaza, Los Angeles, CA 90095, USA. Electronic address: alexandracreed@g.ucla.edu.
Junghee LeeDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA; Veterans Affairs Greater Los Angeles Health Care System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA. Electronic address: jungheelee@ucla.edu.
Michael F GreenDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA; Veterans Affairs Greater Los Angeles Health Care System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA. Electronic address: mgreen@ucla.edu.
Holly K HamiltonSan Francisco Veterans Affairs Health Care System, 4150 Clement Street, San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave., San Francisco, CA 94143, USA. Electronic address: Holly.Hamilton@ucsf.edu.
Gregory A MillerDepartment of Psychology, University of California, Los Angeles, Franz Hall, 502 Portola Plaza, Los Angeles, CA 90095, USA; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: gamiller@ucla.edu.
Kenneth L SubotnikDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: ksubotnik@mednet.ucla.edu.
Joseph VenturaDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: JVentura@mednet.ucla.edu.
Keith H NuechterleinDepartment of Psychology, University of California, Los Angeles, Franz Hall, 502 Portola Plaza, Los Angeles, CA 90095, USA; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: keithn@ucla.edu.
Cindy M YeeDepartment of Psychology, University of California, Los Angeles, Franz Hall, 502 Portola Plaza, Los Angeles, CA 90095, USA; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: yee@psych.ucla.edu.
University of California, Los Angeles · USWest Los Angeles College · USSan Francisco VA Medical Center · US

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2003 to 2014
$18.6M
Enhancing Cognitive Training Through Exercise Following a First Schizophrenia EpisodeR01MH110544 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2016 to 2022
$7.3M
DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSR01MH037705 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 1985 to 2010
$5.1M
Cognitive and Affective Dysfunctions in the PsychosesT32MH096682 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2013 to 2018
$1.1M
NIMH NIH HHS P50 MH066286NIMH NIH HHS R01 MH037705NIMH NIH HHS R01 MH110544NIMH NIH HHS T32 MH096682
6 · The paper itself

Abstract

Schizophrenia (SZ) is associated with impaired adaptive functioning, including difficulties managing the demands of independent living, work, school, and interpersonal relationships. Prior studies have linked the physiological stress response with less effective coping in daily life. Differences in stress-response tendencies may also support heterogeneity in daily functioning in SZ. The present study examined two established measures of the stress response in patients with first-episode SZ. Salivary cortisol was included as an index of hypothalamic-pituitary-adrenal response. Vagal suppression (VS), a measure of stress-related reduction in heart rate variability, was used to assess parasympathetic flexibility. Greater cortisol response and VS to social-evaluative stress were predicted to be associated with better functioning in SZ over and above relationships with social cognition and neurocognition, two well-established predictors of functional outcome. Thirty-eight first-episode SZ outpatients and 29 healthy comparison subjects (HC) provided social cognitive, neurocognitive, and physiological measurements before and after the Trier Social Stress Test (TSST). Although SZ and HC did not differ on VS to the TSST, patients exhibited significant associations between VS and functioning across all four domains of the Role Functioning Scale. Furthermore, greater VS predicted more effective functioning with friends, beyond the contributions associated with social cognition and neurocognition, and strengthened the positive effects of higher levels of social cognition on independent living/self-care. VS elicited by social-evaluative stress in the laboratory may reflect stress-response tendencies in daily life that are relevant for daily functioning in first-episode SZ.

Indexed as

SchizophreniaAdaptation, PsychologicalHumansHydrocortisoneInterpersonal RelationsStress, PsychologicalHydrocortisoneCortisolFunctional outcomeSchizophreniaStressVagal suppression

Identifiers

PMID31948901
PMCPMC7299766
OpenAlexW2999380849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.