Evidence map›Paper›PMID 31948820›Full record

ArticleVaccine2020

Decreased ratio of influenza-specific IgG versus IgM in response to influenza vaccination in antiretroviral-treated HIV-infected African Americans compared to Caucasians, and its direct correlation with the percentages of peripheral Tfh cells.

Ping Ma, Zhenwu Luo, Jing Qian, Zhongfang Yan, Lumin Zhang, Lisa Martin, Ziyu Wang, Huan Xia, Fangfang Yu, Wei Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ping MaSchool of Medicine, Department of Infectious Disease, Nankai University Second People's Hospital, Nankai University, Tianjin 300192, China; Tianjin STD and AIDS Prevention and Treatment Association, Tianjin 300192, China. Electronic address: 30917046@nankai.edu.cn.
Zhenwu LuoDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
Jing QianSchool of Medicine, Department of Infectious Disease, Nankai University Second People's Hospital, Nankai University, Tianjin 300192, China.
Zhongfang YanSchool of Medicine, Department of Infectious Disease, Nankai University Second People's Hospital, Nankai University, Tianjin 300192, China.
Lumin ZhangDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lisa MartinDivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Ziyu WangSchool of Medicine, Department of Infectious Disease, Nankai University Second People's Hospital, Nankai University, Tianjin 300192, China.
Huan XiaSchool of Medicine, Department of Infectious Disease, Nankai University Second People's Hospital, Nankai University, Tianjin 300192, China.
Fangfang YuSchool of Medicine, Department of Infectious Disease, Nankai University Second People's Hospital, Nankai University, Tianjin 300192, China.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA; Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: jianw@musc.edu.
Nankai University · CNMedical University of South Carolina · USIcahn School of Medicine at Mount Sinai · US

Funding

Intersubtype recombinants for polyvalent anti-HIV vaccineR01AI084816 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GAO, YONG · 2009 to 2013
$3.4M
Synergistic effect of HIV virions and bacterial LPS on memory B cell apoptosisR01AI091526 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2011 to 2015
$1.4M
On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV diseaseR01AI128864 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2017 to 2021
$1.1M
NIAID NIH HHS R01 AI084816NIAID NIH HHS R01 AI091526NIAID NIH HHS R01 AI128864
6 · The paper itself

Abstract

backgroundRacial differences have been observed in the rate of bacterial infection and disease progression in HIV. Here, we evaluate racial differences in seasonal influenza vaccine responses.

methods16 healthy controls (9 Caucasians (CC) and 7 African Americans (AA)) and 26 antiretroviral therapy (ART)-treated aviremic HIV+ subjects (11 CC and 15 AA) were enrolled in the current study. Blood was collected at pre-vaccination (D0) and day 14 (D14) following seasonal influenza vaccination. Serologic responses were characterized in plasma by ELISA. B and T cells were assessed by flow cytometry ex vivo.

resultsThe absolute counts of CD4+ CD3+ T cells and CD19+ B cells were similar in healthy controls and HIV-infected individuals, and similar in CC and AA in the two study groups. However, the percentage of peripheral T follicular helper (pTfh) cells was decreased in HIV+ AA compared to HIV+ CC. There were no racial differences in IgG antibody responses against vaccination in the two study groups. However, the ratio of anti-influenza-specific IgG versus IgM induction following vaccination was decreased in HIV+ AA compared to HIV+ CC, which was directly correlated with the percentages of pTfh cells. This racial difference and correlation were not demonstrable in healthy controls.

conclusionHere we report that HIV + AA has decreased fold induction of IgG versus IgM after influenza vaccination, which may suggest impaired class-switching from IgM to IgG in AA HIV-infected individuals.

Indexed as

HIV InfectionsInfluenza, HumanAdultAntibodies, ViralBlack or African AmericanCase-Control StudiesFemaleHumansImmunoglobulin Class SwitchingImmunoglobulin GImmunoglobulin MInfluenza VaccinesMaleMiddle AgedT Follicular Helper CellsVaccinationAntibodies, ViralImmunoglobulin GImmunoglobulin MInfluenza VaccinesAntibody responsesB cellsHIV diseaseInfluenza vaccine

Identifiers

PMID31948820
PMCPMC7333243
OpenAlexW2998900717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.