ArticleNeurobiology of aging2020
Impact of BDNF and sex on maintaining intact memory function in early midlife.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of exercise alone and in combination with time-restricted eating on cognitive health in menopausal women.Frontiers in public health · 2025Trial
- The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease.Neurobiology of aging · 2026Article
- Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.Journal of Alzheimer's disease : JAD · 2025Article
- A Systems Biology Approach to Memory Health: Integrating Network Pharmacology, Gut Microbiota, and Multi-Omics for Health Functional Foods.International journal of molecular sciences · 2025Review
- The interaction of BDNF with estrogen in the development of hypertension and obesity, particularly during menopause.Frontiers in endocrinology · 2024Review
- The therapeutic potential of irisin to mitigate the risk of metabolic syndrome in postmenopausal women.Frontiers in reproductive health · 2024Review
- Buckwheat tartary regulates the Gsk-3β/β-catenin pathway to prevent neurobehavioral impairments in a rat model of surgical menopause.Metabolic brain disease · 2023Article
- Dimethyl fumarate improves cognitive impairment by enhancing hippocampal brain-derived neurotrophic factor levels in hypothyroid rats.BMC endocrine disorders · 2022Article
- Resveratrol Ameliorates Trigeminal Neuralgia-Induced Cognitive Deficits by Regulating Neural Ultrastructural Remodelling and the CREB/BDNF Pathway in Rats.Oxidative medicine and cellular longevity · 2022Article
- Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.Endocrinology · 2021Review
- Exercise and estrogen: common pathways in Alzheimer's disease pathology.American journal of physiology. Endocrinology and metabolism · 2021Review
- Gut permeability and cognitive decline: A pilot investigation in the Northern Manhattan Study.Brain, behavior, & immunity - health · 2021Article
- BDNF expression mediates verbal learning and memory in women in a cohort enriched with risk for Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Sex steroid hormones and neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), play a significant neuroprotective role in memory circuitry aging. Here, we present findings characterizing the neuroprotective effects of BDNF on memory performance, as a function of sex and reproductive status in women. Participants (N = 191; mean age = 50.03 ± 2.10) underwent clinical and cognitive testing, fMRI scanning, and hormonal assessments of menopausal staging. Memory performance was assessed with the 6-Trial Selective Reminding Test and the Face-Name Associative Memory Exam. Participants also performed a working memory (WM) N-back task during fMRI scanning. Results revealed significant interactions between menopausal status and BDNF levels. Only in postmenopausal women, lower plasma BDNF levels were associated with significantly worse memory performance and altered function in the WM circuitry. BDNF had no significant impact on memory performance or WM function in pre/perimenopausal women or men. These results suggest that in postmenopausal women, BDNF is associated with memory performance and memory circuitry function, thus providing evidence of potential sex-dependent factors of risk and resilience for early intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.