Observational studyJournal of developmental origins of health and disease2021
Maternal cardiometabolic factors and genetic ancestry influence epigenetic aging of the placenta.
Observational study in Journal of developmental origins of health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Late-onset preeclampsia is characterized by accelerated placental aging.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics.iScience · 2025Article
- Maternal obesity and ancestry distance in influencing birth outcomes.International journal of obesity (2005) · 2025Observational
- Early life epigenetics and childhood outcomes: a scoping review.Pediatric research · 2025Article
- Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration.Clinical epigenetics · 2025Article
- Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study.Research square · 2024Article
- Characterizing epigenetic aging in an adult sickle cell disease cohort.Blood advances · 2024Article
- Placental accelerated aging in antenatal depression.American journal of obstetrics & gynecology MFM · 2024Article
- Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns.JAMA network open · 2023Article
- Epigenetic clocks and female fertility timeline: A new approach to an old issue?Frontiers in cell and developmental biology · 2023Review
- The influence of early environment and micronutrient availability on developmental epigenetic programming: lessons from the placenta.Frontiers in cell and developmental biology · 2023Review
- An integrative framework and recommendations for the study of DNA methylation in the context of race and ethnicity.Discover social science and health · 2023Review
- Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps.Epigenetics · 2022Review
- A biosocial return to race? A cautionary view for the postgenomic era.American journal of human biology : the official journal of the Human Biology Council · 2022Review
- Prenatal Exposure to Ambient Air Pollution and Epigenetic Aging at Birth in Newborns.Frontiers in genetics · 2022Article
- Characteristics of epigenetic aging across gestational and perinatal tissues.Clinical epigenetics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Disruption of physiological aging of the placenta can lead to pregnancy complications and increased risk for cardiometabolic diseases during childhood and adulthood. Maternal metabolic and genetic factors need to operate in concert with placental development for optimal pregnancy outcome. However, it is unknown whether maternal cardiometabolic status and genetic ancestry contribute to differences in placental epigenetic age acceleration (PAA). We investigated whether maternal prepregnancy obesity, gestational weight gain (GWG), blood pressure, and genetic ancestry influence PAA. Among 301 pregnant women from 4 race/ethnic groups who provided placenta samples at delivery as part of the National Institute of Child Health and Human Development Fetal Growth Studies, placental DNA methylation age was estimated using 62 CpGs known to predict placental aging. PAA was defined to be the difference between placental DNA methylation age and gestational age at birth. Percentage of genetic ancestries was estimated using genotype data. We found that a 1 kg/week increase in GWG was associated with up to 1.71 (95% CI: -3.11, -0.32) week lower PAA. Offspring Native American ancestry and African ancestry were associated, respectively, with higher and lower PAA among Hispanics, and maternal East Asian ancestry was associated with lower PAA among Asians (p < 0.05). Among mothers with a male offspring, blood pressure was associated with lower PAA across all three trimesters (p < 0.05), prepregnancy obesity compared to normal weight was associated with 1.24 (95% CI: -2.24, -0.25) week lower PAA. In summary, we observed that maternal cardiometabolic factors and genetic ancestry influence placental epigenetic aging and some of these influences may be male offspring-specific.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.