Evidence map›Paper›PMID 31948469›Full record

ArticleJournal of medical case reports2020

Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren's syndrome and rheumatoid arthritis: a case report.

Vadim R Gorodetskiy, Natalya A Probatova, Dmitry M Konovalov, Natalya V Ryzhikova, Yulia V Sidorova, Andrey B Sudarikov, Olga V Mukhortova

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In one paragraph

Article in Journal of medical case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Vadim R GorodetskiyDepartment of Intensive Methods of Therapy, V.A. Nasonova Research Institute of Rheumatology, Kashirskoye shosse 34А, Moscow, 115522, Russia. gorodetskiyblood@mail.ru.
Natalya A ProbatovaDepartment of Pathology, N.N. Blokhin Russian Cancer Research Center, Kashirskoye shosse 24, Moscow, 115478, Russia.
Dmitry M KonovalovDepartment of Pathology, Dmitry Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Leninsky Prospect, 117, Moscow, 117513, Russia.
Natalya V RyzhikovaLaboratory of Molecular Hematology, National Hematology Research Center, Novy Zykovskiy Proezd, 4a, Moscow, 125167, Russia.
Yulia V SidorovaLaboratory of Molecular Hematology, National Hematology Research Center, Novy Zykovskiy Proezd, 4a, Moscow, 125167, Russia.
Andrey B SudarikovLaboratory of Molecular Hematology, National Hematology Research Center, Novy Zykovskiy Proezd, 4a, Moscow, 125167, Russia.
Olga V MukhortovaDepartment of Nuclear Diagnostics, A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Roublyevskoe Shosse 135, Moscow, 121552, Russia.
Endocrinology Research Center · RUBakulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences · RUDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RURussian Cancer Research Center NN Blokhin · RUVA Nasonova Scientific Research Institute of Rheumatology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpstein-Barr virus is associated with many human hematopoietic neoplasms; however, Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma is extremely rare. In routine clinical practice, detection of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in a tissue sample presumes a clonal relation between these neoplasms and that diffuse large B-cell lymphoma developed by transformation of the mucosa-associated lymphoid tissue lymphoma. However, evidence to support this presumption is sparse and controversial. Assessment of the clonal relationship of the lymphoid components of a composite lymphoma is important for understanding its pathogenesis and correct diagnosis. CASE PRESENTATION: We present an unusual case of composite lymphoma (Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma/Epstein-Barr virus-negative diffuse large B-cell lymphoma) in the parotid salivary gland of a 62-year-old Caucasian woman with Sjögren's syndrome and rheumatoid arthritis. Simultaneous occurrence of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in the parotid salivary gland led us to initially assume a clonal relationship between diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma. Epstein-Barr virus was detected by in situ hybridization and polymerase chain reaction in the mucosa-associated lymphoid tissue lymphoma, but not in diffuse large B-cell lymphoma, suggesting that these lymphomas were not clonally related. Fragment analysis of frame region 3 polymerase chain reaction products from microdissected mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma components revealed different clonal pattern rearrangements of the immunoglobulin heavy chain gene.

conclusionsOur patient's case highlights the importance of assessing the clonal relationships of the lymphoid components of a composite lymphoma and Epstein-Barr virus screening in mucosa-associated lymphoid tissue lymphoma in patients with autoimmune disease.

Indexed as

Arthritis, RheumatoidComposite LymphomaEpstein-Barr Virus InfectionsFemaleGene Rearrangement, B-LymphocyteHumansLymphoma, B-Cell, Marginal ZoneLymphoma, Large B-Cell, DiffuseMiddle AgedParotid NeoplasmsPolymerase Chain ReactionSalivary GlandsSjogren's SyndromeAutoimmune diseasesComposite lymphomaDiffuse large B-cell lymphomaEpstein-Barr virusMucosa-associated lymphoid tissue lymphoma

Identifiers

PMID31948469
PMCPMC6966905
OpenAlexW3007620619

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.